自噬和凋亡在肌少症中的研究进展  

Roles of Autophagy and Apoptosis in Sarcopenia

作　　者：贡歌 杨翔[1] 殷建 张兴虎[1] 张瑗[1] 万文辉[1] 

机构地区：[1]中国人民解放军南京总医院干部病房一科,南京210002 [2]南京医科大学附属江宁医院骨科,南京211100

出　　处：《中国医学科学院学报》2018年第1期112-115,共4页Acta Academiae Medicinae Sinicae

基　　金：全军保健专项基金(13BJZ11);南京军区医学卫生科研基金(11MA101);中国人民解放军南京总医院院管课题(2017065)~~

摘　　要：肌少症是与年龄相关的骨骼肌质量和功能进行性和全身性的损失,其原因为运动、营养、遗传因素、内分泌因素、炎症等,病理生理机制包括线粒体功能障碍、凋亡的过度激活、自噬的调节异常、卫星细胞功能的下降,活性氧产生增加等,本文总结了自噬及凋亡与肌少症的关系,并对调节自噬及减少凋亡在肌少症中的应用前景进行了展望。Sarcopenia is an aged-related progressive and systemic loss of skeletal muscle mass and functions.It may be caused by factors such as exercise,nutrition,genetic factors,endocrine factors,and inflammation.The pathophysiological mechanisms include mitochondrial dysfunction,excessive activation of apoptosis,dysregulation of autophagy,abnormal function of satellite cells,and aggregation of reactive oxygen species.This article summarizes the relationships of autophagy and apoptosis with sarcopenia and discusses the values of autophagy regulation and apoptosis reduction in the management of sarcopenia.

关 键 词：肌少症 病理生理机制 自噬 凋亡 

分 类 号：R592[医药卫生—老年医学]