机械通气对ICU肺动脉高压伴呼吸衰竭患者血浆脑钠肽水平的影响分析  

The effect of mechanical ventilation on the plasma brain natriuretic peptide level in patients with ICU pulmonary hypertension and respiratory failure

作　　者：黄志成 刘茂波 李泉森 蔡贵先 侯绍河 张建通 

机构地区：[1]广东省封开县人民医院重症医学科,广东封开526500

出　　处：《中国医药科学》2018年第3期223-226,共4页China Medicine And Pharmacy

摘　　要：目的探讨机械通气对ICU肺动脉高压伴呼吸衰竭患者血浆脑钠肽水平的影响。方法选取2016年5月22日~2017年5月22日期间我院收治的100例ICU肺动脉高压伴呼吸衰竭患者,将其抽签化分组,两组各有50例,对照组和观察组分别采用无创机械通气治疗和有创机械通气治疗。结果观察组患者的BE(5.32±1.02)mmol/L、BB(3.20±0.11)mmol/L、HCO_2(24.17±1.66)mmol/L、SaO_2(0.98±0.88)、PaCO_2(42.95±2.14)mmHg、PaO_2(97.48±2.28)mmHg、MAP(83.12±2.95)%、RR(20.12±1.75)次/min、HR(95.25±3.66)次/min、BNP(358.12±12.85)pg/mL、CGRP(95.85±5.14)ng/mL、ANP(182.36±5.23)ng/mL、OI(14.23±2.55)、ET-1(65.11±5.15)ng/m L、并发症发生率(2.00%)均优于对照组(P<0.05)。结论对ICU肺动脉高压伴呼吸衰竭患者实施有创机械通气治疗,能够加快血浆脑钠肽水平的改善。Objective To explore the effect of mechanical ventilation on plasma brain natriuretic peptide level in patients with pulmonary hypertension and respiratory failure in ICU. Methods One hundred patients with pulmonary hypertension associated with respiratory failure in ICU from May 22, 2016 to May 22, 2017 were selected and divided into two groups, with 50 cases in each group. The control group and the observation group were treated with noninvasive mechanical ventilation and invasive mechanical ventilation respectively. Results BE(5.32±1.02) mmol/L,BB(3.20±0.11) mmol/L, HCO_2(24.17 ±1.66) mmol/L, SaO_2(0.98±0.88), PaCO_2(42.95±2.14) mmHg, PaO_2(97.48±2.28) mmHg, MAP(83.12±2.95)%, RR(20.12±1.75)/min, HR(95.25±3.66)/min, BNP(358.12±12.85) pg/mL, CGRP(95.85±5.14) ng/mL, ANP(182.36±5.23) ng/mL, OI(14.23 ±2.55), ET-1(65.11±5.15) ng/m L, the incidence of complications(2%) in the observation group were better than those in the control group(P < 0.05). Conclusion Invasive mechanical ventilation can accelerate the improvement of plasma brain natriuretic peptide(BNP) in patients with ICU pulmonary hypertension and respiratory failure.

关 键 词：机械通气 肺动脉高压 呼吸衰竭 血浆脑钠肽 

分 类 号：R544.1[医药卫生—心血管疾病] R563.8[医药卫生—内科学]