芪明颗粒的应用可改善T2DM患者眼科手术后干眼症  

Improvement Effects of the Application of Qiming Granule on Dry Eye after Eye Surgery for Patients with T2DM

作　　者：赵智华[1] 樊芳[1] 马清敏[1] 赵晓彬[1] 

机构地区：[1]河北省人民医院

出　　处：《基因组学与应用生物学》2018年第1期80-86,共7页Genomics and Applied Biology

基　　金：河北省人民医院资助

摘　　要：为探讨2型糖尿病（T2DM）患者超声乳化术后干眼并角膜上皮损伤患者应用芪明颗粒治疗的临床效果,本研究选取了80例病例患者（100眼）（2014年8月至2016年5月）进行研究,其中40例（50眼）采用普拉洛芬、玻璃酸钠滴眼液治疗（对照组）、40例患者在对照组基础上加用芪明颗粒治疗（观察组）,对比两组效果。研究发现,治疗前,两组患者的泪膜破裂时间、5 min Schirmer值差异无统计学意义（p〉0.05）;治疗后,观察组患者的泪膜破裂时间、5 min Schirmer值均显著的大于对照组（p〈0.05）;治疗前,两组患者的角膜荧光素染色评分、结膜充血症状评分差异无统计学意义（p〉0.05）;治疗后,观察组患者的角膜荧光素染色评分、结膜充血症状评分均显著的低于对照组（p〈0.05）;治疗后,观察组患者的治愈58.00%、显效36.00%、有效6.00%,对照组治愈40.00%、显效38.00%、有效18.00%、无效4.00%,两组比较差异具有统计学意义（p〈0.05）。研究表明,T2DM患者超声乳化术后干眼并角膜上皮损伤患者应用芪明颗粒治疗能够进一步提升临床治疗效果,具备临床进一步推广应用的价值。To investigate the clinical effect of Qiming granule in the treatment of dry eye and corneal epithelial wound in patients with type 2 diabetes mellitus（T2 DM） after phacoemulsification, 80 patients with this disease（100 eyes）（August 2014 to May 2016） were selected in this study. 40 patients（50 eyes） were treated with pranoprofen and hyaluronic acid sodium eye drops（control group）, and Qiming granule were added in the treatment of other 40 patients on the basis of the control group（observation group）, and the effects were compared. It was found that theere was no significant difference in tear film breakup time and 5 min Schirmer value between the two groups before treatment（P〈0.05）. After treatment, the tear film breakup time and 5 min Schirmer value of the observation group were significantly higher than those of the control group（P〈0.05）. There was no significant difference in corneal fluorescein staining scores and conjunctival hyperemia scores between the two groups before treatment（P〈0.05）. After treatment, the corneal fluorescein staining scores and conjunctival hyperemia scores were significantly lower than those of the control group（P〈0.05）. After treatment, the patients in the observation group were cured 58.00%,markedly effective 36.00%, effective 6.00%, while the control group was cured 40.00%, markedly effective38.00%, effective 18.00%, ineffective 4.00%. The difference was statistically significant（P〈0.05）. It indicated that the application of Qiming granule could further enhance clinical therapeutic effect for dry eye and corneal epithelial wound in patients with type 2 diabetes mellitus（T2DM） after phacoemulsification, which might have further value in clinical application.

关 键 词：2型糖尿病 超声乳化术 干眼症 角膜上皮损伤 芪明颗粒 

分 类 号：R587.2[医药卫生—内分泌] R779.6[医药卫生—内科学]