丁香骨痛方外敷联合阿片类药物治疗骨转移癌痛阴证的临床研究  

Clinical Study on The Treatment of Bone Metastasis Cancer Pain Syndrome with Ding Xiang Gu Tong Recipe and Opioids

作　　者：陈宏[1] 张双双 杨科 孙韬[1] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]桓兴肿瘤医院,北京100122

出　　处：《中国中医基础医学杂志》2018年第1期108-110,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：北京中医药大学科研基金中青年教师类面上项目(2015-JYB-JSMS097)-丁香骨痛方外敷护理干预对骨转移癌痛阴证及血浆内皮素-1水平的影响

摘　　要：探究丁香骨痛方外敷联合阿片类药物治疗骨转移癌痛阴证的临床疗效。方法:选取2015年7月至2017年2月北京中医药大学东方医院肿瘤科住院的骨转移癌痛阴证患者80例,采用随机、双盲、安慰剂平行对照的临床研究方法分为治疗组和对照组各40例。治疗组患者采用丁香骨痛方穴位贴敷+阿片类药物治疗,对照组采用安慰剂+阿片类药物治疗,疗程均为7 d,观察治疗前后2组患者的止痛疗效、生活质量、阿片类药物不良反应、血浆ET-1浓度等。结果:中重度骨转移癌痛患者在阿片类药物治疗基础上,加用丁香骨痛方穴位贴敷可进一步减轻疼痛,降低血浆ET-1浓度,缓解患者便秘症状,改善患者的生活质量。To explore the clinical efficacy of Ding Xiang Gu Tong Recipe Combined with Opioids in the treatment of bone metastases cancer pain syndrome. Methods： A total of 80 patients with bone metastatic cancer pain syndrome selected from July 2015 to February 2017 in the department of oncology of Beijing University of Chinese Medicine Dong fang hospital were treated with randomized,double-blind,placebo-controlled clinical study. The patients were divided into treatment group（ 40 cases） and control group（ n = 40）. The treatment group was given＂Ding Xiang Gu Tong Recipe＂acupoints ＋opioid therapy,the control group was given ＂Ding Xiang Gu Tong Recipe＂placebo point paste ＋ opioid therapy for 7 days. We observe the patient＇s analgesic effect,quality of life,Opioid adverse drug reactions and plasma endothelin-1 concentration etc. Results： In patients with moderate to severe bone metastases cancer pain syndrome,on the basis of opioid therapy,the addition of＂Ding Xiang Gu Tong Recipe＂acupoint application can further reduce the pain,reduce the plasma ET-1 concentration,relieve symptoms of patients with constipation,and improve the quality of life of patients.

关 键 词：丁香骨痛方 骨转移癌痛 血浆ET-1 

分 类 号：R289.5[医药卫生—方剂学]