添加不同辅料牛膝浸膏粉体表面特征与吸湿性的相关性  

Correlation between surface features and hygroscopicities of Achyranthis bidentatae Radix extract powders added with different excipients

作　　者：孙道开[1] 范益芹 

机构地区：[1]连云港市第一人民医院药学部,江苏连云港222000 [2]连云港市急救中心护理部,江苏连云港222000

出　　处：《中成药》2018年第2期326-330,共5页Chinese Traditional Patent Medicine

摘　　要：目的考察添加不同辅料牛膝Achyranthis bidentatae Radix浸膏粉体表面特征与吸湿性的相关性。方法牛膝水提液分别添加交聚维酮CL-SF、麦芽糊精DE11-14、β-环糊精、阿拉伯胶、糊精、甘露醇、可溶性淀粉、乳糖后制备浸膏粉体,测定其吸湿性及形态变化,再通过双指数模型比较各浸膏粉体的表面特征。结果与其他辅料相比,可溶性淀粉、β-环糊精可更明显地降低浸膏粉体饱和吸湿量,交聚维酮CL-SF对粉体吸湿后黏连的抑制作用最强。吸湿性与比表面积、孔容无直接关系,但比表面积、孔容、平均粒径与模型参数A1呈正相关。结论合适辅料的添加可改善牛膝浸膏粉体的表面特征和吸湿性。AIM To investigate the correlation between surface features and hygroscopicities of Achyranthis bidentatae Radix extract powders added with different excipients. METHODS Achyranthis bidentatae Radix aqueous extract was added with crospovidone CL-SF,maltodextrin DE11-14,β-cyclodextrin,Arabic gum,dextrin,mannitol,soluble starch and lactose,respectively,after which extract powders were prepared,and hygroscopicities and morphological changes were determined. Then the surface features of various extract powders were compared by double exponential model. RESULTS Compared with other excipients,soluble starch and β-cyclodextrin could reduce the saturated moisture content of the extract powders more obviously,and crospovidone CL-SF exhibited the strongest inhibitory effect on powder synechia after moisture absorption. No direct relationship between hygroscopicities and specific surface area or pore volume was observed,but specific surface area,pore volume and average particle size demonstrated positive correlations with model parameter A1. CONCLUSION Addition of proper excipients can improve the surface features and hygroscopicities of Achyranthis bidentatae Radix extract powders.

关 键 词：牛膝 浸膏粉体 辅料 表面特征 吸湿性 双指数模型 

分 类 号：R944[医药卫生—药剂学]