不同级别大剂量激素对急性百草枯中毒患者疗效研究  

Effects of different levels of high-dose steroid in patients with acute paraquat poisoning

作　　者：宋凤麟[1] 闫新明[1] 穆进军[1] 王晓娟 黄静 逯林欣[1] 杨美霞[1] 方雅琴[1] 温继兰 

机构地区：[1]山西医学科学院山西大医院急诊医学科,太原030032 [2]山西医学科学院山西大医院科教处,太原030032

出　　处：《中国药物与临床》2018年第2期153-156,共4页Chinese Remedies & Clinics

基　　金：山西省科技厅科技攻关项目(20140313012-7)

摘　　要：目的探讨不同级别大剂量甲泼尼龙对急性百草枯中毒患者的疗效及及安全性。方法将按纳入和排除标准入选的37例患者随机分为2组,较低剂量组(甲泼尼龙7.5 mg·kg^(-1)·d^(-1),最大剂量不超过500mg)和较高剂量组(甲泼尼龙15 mg·kg^(-1)·d^(-1),最大剂量不超过1 000 mg),观察2组疗效差别及激素并发症发生情况。结果 2组患者的病死率差异无统计学意义,2组患者中死亡患者的存活时间差异无统计学意义;2组患者的激素相关并发症发生差异有统计学意义,较高剂量组更多见不良反应的发生。结论较低剂量甲泼尼龙冲击治疗方案在治疗急性百草枯中毒患者方面与较高剂量冲击治疗方案比较疗效差异无统计学意义,且不良反应发生率低。Objective To investigate the effects and safety of different levels of high-dose methylprednisolone （MP） in patients with acute paraquat （PQ） poisoning. Methods According to inclusion and exclusion criteria, thirty- seven patients were included and randomly divided into the lower-dose therapy group （7.5 mg·kg^-l·d^-1 MP, with the maximum dose not exceeding 500 mg） and higher-dose therapy group （15 mg·kg^-l·d^-1 MP, with the maximum dose not exceeding 1 000 mg）. The different effects and occurrence of hormone-related complications between the two groups were determined. Results There was no statistically significant difference in the mortality between the two groups. There was no statistically significant difference in the survival time of deceased patients between the two groups. There were statistically significant differences in the hormone-related comjplications between the two groups, with more ad- verse reactions occurring in the higher-dose group. Conclusion There is no statistically significant difference in the treatment of acute PQ poisoning between the lower-dose MP shock therapy and higher-dose MP shock therapy, and the incidence of adverse reactions is low.

关 键 词：百草枯 中毒 甲泼尼龙 剂量 疗效 并发症 

分 类 号：R595.4[医药卫生—内科学]