天癸方对多囊卵巢综合征大鼠性激素及胰岛素抵抗的影响  

Effect of Tiangui Recipe on sex hormone and insulin resistance in rats with polycystic ovary syndrome

作　　者：邓晶[1] 王敏[1] 罗菁[1] 应伊丽[1] 

机构地区：[1]武汉市第一医院,武汉430022

出　　处：《吉林中医药》2018年第1期64-67,共4页Jilin Journal of Chinese Medicine

基　　金：湖北省卫计委临床医学科研项目(WX16C04)

摘　　要：目的探讨天癸方对多囊卵巢综合征(Polycystic ovary syndrome,PCOS)大鼠性激素及胰岛素抵抗影响性。方法选择健康雌性大鼠50只,分成5组,每组均为10只,分别为正常对照组、模型组、中药治疗组、西药治疗组、中西医结合治疗组,正常对照组仅正常饲养,余4组采用硫酸普拉睾酮钠配合高脂饮食建立胰岛素抵抗的PCOS大鼠模型,分别予生理盐水、天癸方、二甲双胍、天癸方+二甲双胍治疗,抽取大鼠静脉血,观察在血清睾酮(T)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、胰岛素样生长因子-1(IGF-1)、空腹血糖(FBG)、胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)水平变化情况。结果中药组、西药组、中西医结合治疗组在T、LH、LH/FSH、IGF-1、E2上较模型组显著下降,FSH则显著升高,组间比较差异有统计学意义(P<0.05),而中西医结合治疗组较中药组、西药组在以上指标上改善更加显著,差异有统计学意义(P<0.05);模型组在FBG、FINS、HOMA-IR水平上最高,ISI水平最低,和其他组别比较差异有统计学意义(P<0.05),中药组和西药组在FBG、FINS、ISI、HOMA-IR水平比较差异无统计学意义(P>0.05),而中西医结合治疗组在FBG、FINS、ISI、HOMA-IR水平上改善最显著,差异有统计学意义(P<0.05)。结论天癸方能调节胰岛素抵抗的PCOS大鼠糖代谢紊乱,能改善高胰岛素血症和高雄激素血症。Objective To investigate the effect of Tiangui Recipe on sex hormone and insulin resistance in rats with polycystic ovary syndrome.Methods 50 healthy female rats were divided into 5 groups,10 rats in each group respectively,the normal control group,model group,Chinese medicine treatment group,treatment group and western medicine combined traditional Chinese medicine and western medicine treatment group,The normal control group was only reared,and the remaining 4 groups were used to establish the PCOS rat model of insulin resistance with sodium prastoptestosterone sulfate and high fat diet,the rats were treated with normal saline,Tiangui Recipe,metformin,Tiangui Recipe ＋ metformin,and the venous blood of rats was extracted,venous blood of rats were observed in serum testosterone（T）,follicle stimulating hormone（FSH） and luteinizing hormone（LH）,estradiol（E2）,insulin-like growth factor-1（IGF-1）,fasting blood glucose（FBG） and insulin resistance index（HOMA-IR）,insulin sensitivity index（ISI） changes.Results The traditional Chinese medicine group,western medicine group and integrative medicine group decreased significantly in T,LH,LH/FSH,IGF-1 and E2 compared with the model group,while FSH increased significantly,the difference between the two groups was statistically significant（P〈0.05）,compared with the traditional Chinese medicine group and the western medicine group,above indexes of the combined traditional Chinese medicine and western medicine treatment group was more significant than the traditional Chinese medicine group and the western medicine group.The difference was statistically significant（P〈0.05）; model group was the highest in FBG,FINS,HOMA-IR level,ISI level was the lowest,and the other groups had significant difference（P〈0.05）,Chinese medicine group and Western medicine group had no difference in FBG,FINS,ISI,HOMA-IR（P〉0.05）,and the combination therapy group in FBG,FINS,ISI,HOMA-IR the level of the most significant improvement（P〈0.05）.Conclu

关 键 词：天癸方 多囊卵巢综合征 大鼠 性激素 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]