麦滋林联合标准三联疗法治疗儿童幽门螺杆菌阳性消化性溃疡的疗效及对血清胃蛋白酶原、胃肠激素的影响  

Marzulene-S combined with standard triple therapy for treatment of children with Helicobacter pylori positive peptic ulcer:Efficacy and influence on serum pepsinogen and gastrointestinal hormones

作　　者：王金珠 贾彩华 

机构地区：[1]天津市宁河区医院儿科,天津市301500

出　　处：《世界华人消化杂志》2018年第1期41-46,共6页World Chinese Journal of Digestology

摘　　要：目的探讨麦滋林联合标准三联疗法治疗幽门螺杆菌(Helicobacter pylori,H.pylori)阳性消化性溃疡(peptic ulcer,PU)患儿的疗效及对血清胃蛋白酶原(pepsinogen,PG)、胃肠激素水平的影响.方法入选144例H.pylori阳性PU患儿采用随机数字表法分为观察组与对照组,每组72例.对照组给予标准三联疗法(奥美拉唑+克拉霉素+阿莫西林)治疗,观察组在对照组基础上加用麦滋林治疗.比较两组临床疗效、H.pylori根除率及药物不良反应,治疗前后检测血清PGⅠ、PGⅡ、胃泌素(gastrin,GAS)、生长抑素(somatostatin,SS)水平,并与30例健康体检儿童(健康组)进行比较.结果观察组治疗总有效率优于对照组(97.22%vs 84.72%),组间比较差异有统计学意义(P<0.05).与健康组比较,两组治疗前血清PGⅠ、PGⅡ、SS均明显升高而SS明显降低(P<0.05).与本组治疗前比较,两组治疗后血清均明显升高,GAS均明显降低(P<0.05);与对照组同期比较,观察组治疗后血清PGⅠ、PGⅡ、SS明显升高,而GAS均明显降低,差异均有统计学意义(P<0.05).观察组药物不良反应发生率为4.17%,与对照组(6.94%)比较,差异无统计学意义(P>0.05).结论麦滋林联合标准三联疗法治疗H.pylori阳性PU患儿能够有效调节血清PG及胃肠激素水平,提高临床疗效,且药物不良反应少.AIM To evaluate the efficacy of marzulene-S combined with standard triple therapy in the treatment of children with Helicobacter pylori （H. pylori） positive peptic ulcer （PU）, and to observe the effect on serum pepsinogen （PG） and gastrointestinal hormones. METHODS A total of 144 children with H. pylori positive PU were randomly divided into either an observation group or a control group, with 72 cases in each group. Both groups were treated with standard triple therapy （omeprazole ＋ clarithromycin ＋ amoxicillin）, and the observation group was additionally given marzulene-S. The clinical efficacy, eradication rate of H. pylori and adverse drug reaction rate were compared between the two groups. Serum levels of PG I, PG II, gastrin （GAS）, and somatostatin （SS） were measured in all patients before and after treatment, and the results were compared with those of 30 healthy children who received physical examination at our hospital. The total effective rate was significantly higher in the observation group than in the control group （97.22% vs 84.72%, P 〈 0.05）. Compared with the healthy control group, serum levels of PG I, PG II, and SS were significantly higher, and that of SS was significantly lower in the two patient groups before treatment （P 〈 0.05）. Serum levels of PG I, PG II, and SS significantly decreased, and that of SS significantly increased in the two patient groups after treatment compared with pretreatment levels （P 〈 0.05）. Compared with the control group, serum levels of PG I, PG II, and SS were significantly lower, and that of SS was significantly higher in the observation group after treatment （P 〈 0.05）. The incidence of adverse drug reactions was 4.17% in the observation group and 6.94% in the control group, which showed no statistical difference （P 〉 0.05）.CONCLUSION Marzulene-S combined with standard triple therapy can regulate serum levels of PG and gastrointestinal hormones in children with H. pylori positive PU, improve the clinical c

关 键 词：消化性溃疡 幽门螺杆菌 儿童 麦滋林 标准三联疗法 胃蛋白酶原 胃肠激素 

分 类 号：R725.7[医药卫生—儿科]