羟氯喹对类风湿关节炎合并2型糖尿病患者血糖和血脂的影响  

Effects of hydroxychloroquine on blood glucose and serum lipids of patients with rheumatoid arthritis and type 2 diabetes mellitus

作　　者：杭元星[1] 任天丽[1] 周红霞[1] 华敏慧[1] 季蓉 

机构地区：[1]无锡市第二人民医院风湿科,江苏214000

出　　处：《江苏医药》2018年第1期66-68,共3页Jiangsu Medical Journal

摘　　要：目的探讨羟氯喹对类风湿关节炎(RA)合并2型糖尿病(T2DM)患者血糖和血脂的影响。方法 RA合并T2DM患者120例随机均分为四组:对照组(C组)口服甲氨蝶呤(每周1次,每次10mg)+二甲双胍(每日2次,每次0.5g),T1、T2和T3组在对照组基础上分别每日口服羟氯喹0.2、0.3和0.4g。观察四组治疗前及治疗10个月后空腹血糖(FPG)、餐后2-血糖(2hPG)、HbA1c、TG、TC和LDL-C的变化。结果治疗后,四组FPG、2hPG、HbA1c、TG、TC和LDL-C均较治疗前降低(P<0.05),T1组、T2组和T3组均低于对照组(P<0.05),T2组和T3组低于T1组(P<0.05),T3组低于T2组(P<0.05)。结论在口服甲氨蝶呤和二甲双胍基础上,羟氯喹能辅助降低RA合并T2DM患者血糖和血脂水平,且呈剂量依赖性。Objective To investigate the effects of hydroxychloroquine on the blood glucose and serum lipids in the patients with rheumatoid arthritis（RA）and type 2 diabetes mellitus（T2 DM）.Methods A total of 120 patients with RA and T2 DM was randomly and equally divided into 4 groups.The patients in group C received oral methotrexate 10 mg once a week plus metformin 0.5 g twice a day for 10 months and those in groups of T1,T2 and T3 were given additional oral hydroxychloroquine 0.2,0.3 and 0.4 g per day for 10 months,respectively.The changes of fasting blood glucose（FPG）,2-hour post-meal blood glucose（2 hPG）,glycosylated hemoglobin（HbA1 c）,triglyceride（TG）,total cholesterol（TC）and low-density lipoprotein cholesterol（LDL-C）in 4 groups were observed before and in 10 months after treatment.Results The levels of FPG,2 hPG,HbA1 c,TG,TC and LDL-C in 4 groups were lower after treatment than those before（P〈0.05）,which were in an order of group T3group T2group T1group C（P〈0.05）.Conclusion On the basis of oral methotrexate and metformin,additional oral hydroxychloroquine is able to further decrease blood glucose and serum lipids in a dose-dependent manner in the patients with RA and T2 DM.

关 键 词：类风湿关节炎 2型糖尿病 羟氯喹 血糖 血脂 

分 类 号：R593[医药卫生—内科学]