白细胞介素10基因多态性与北京地区哮喘病患者的相关性研究  

Association of interleukin-10 gene polymorphism with bronchial asthma in Chinese subjects in Beijing area

作　　者：张旭[1,2] 王玉红 张媛[1,2] 张罗[1,2] 

机构地区：[1]首都医科大学附属北京同仁医院过敏科,北京100730 [2]北京市耳鼻咽喉科研究所,鼻病研究北京市重点实验室,北京100005 [3]首都医科大学附属北京同仁医院呼吸科,北京100730

出　　处：《中国耳鼻咽喉头颈外科》2018年第1期35-37,共3页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：北京市自然科学基金(7164247);首都卫生发展科研专项基金(2016-4-1092);首都医科大学附属北京同仁医院科研基金(2015-YJJ-ZZL-010)联合资助

摘　　要：目的探讨白细胞介素10(IL-10)基因启动子区的3个单核苷酸多态性位点(rs1800896、rs1800871、rs1800872)与哮喘易感性的相关性。方法选取来自我国长期居住在北京地区的205例确诊的哮喘患者和210名健康对照者作为研究对象。采用时间飞行质谱的方法,对选取的rs1800896、rs1800871、rs1800872位点进行基因分型。结果 IL-10rs1800872位点在哮喘组中3种基因型与健康对照组相比具有统计学意义(P=0.016),等位基因频率差异也具有统计学意义(P=0.021)。AA基因型哮喘患者血清的IgE浓度显著升高(P<0.01)。结论 IL-10 rs1800872位点和哮喘的发病相关。OBJECTIVE The objective of this study was to investigate the association between interleukin 10 （IL-10） gene polymorphism and asthma. METHODS We tried to enroll data from 205 asthma patients and 210 controls to investigate the association between IL-10 polymorphisms and asthma in the Han Chinese population. The three common single nucleotide polymorphisms （SNPs）, including rs1800896, rs1800871, rs1800872 on the promoter area of IL-10 were genotyped using the sequenom mass array technology platform. RESULTS Our results showed that rs1800872 were significantly associated with asthma. In asthma groups, we found that there was significant high concentration of total serum IgE in genotype AA comparing with genotype CC. CONCLUSION In conclusion, our data showed that rs1800872 was significantly associated with asthma.

关 键 词：哮喘 白细胞介素10 多态性 单核苷酸 

分 类 号：R562.25[医药卫生—呼吸系统]