维胺酯胶囊内服联合他克莫司软膏治疗脂溢性皮炎的临床疗效  

Clinical efficacy of viaminate capsules combined with tacrolimus ointment in the treatment of seborrheic dermatitis

作　　者：张林 赵宏良 王宁 

机构地区：[1]首都医科大学密云教学医院皮肤性病科,北京101500 [2]首都医科大学密云教学医院烧伤整形美容科,北京101500 [3]首都医科大学密云教学医院皮肤性病科检验科,北京101500

出　　处：《中华医院感染学杂志》2018年第4期551-554,共4页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(81171798)

摘　　要：目的探讨维胺酯胶囊内服联合0.1%他克莫司软膏外用治疗脂溢性皮炎的临床疗效。方法选取医院2011年10月-2015年10月治疗的面部脂溢性皮炎患者426例,分为对照组和研究组,各213例,对照组予以0.1%他克莫司软膏外用治疗,研究组在对照组基础上予以维胺酯胶囊治疗,观察并记录两组间皮肤生理指标、血清炎症因子水平、血清氧化应激反应相关指标水平,同时比较临床疗效及不良反应发生率。结果研究组疗效优于对照组(P<0.001);治疗后两组患者皮肤角质层含水量升高,皮肤经表皮水分丢失量(TEWL)、油脂含量降低,两组以上指标差异有统计学意义(P<0.001);治疗后研究组血清白细胞介素-10(IL-10),过氧化氢酶(CAT)水平和超氧化物歧化酶(SOD)分别为(23.04±3.15)pg/ml,(8.43±1.16)U/ml和(14.27±2.03)U/ml高于对照组(P<0.001),研究组肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、血清丙二醛(MDA)水平分别为(209.05±24.37)pg/ml,(11.02±1.46)pg/ml,(1.26±0.15)mmol/mg低于对照组(P<0.001)。结论维胺酯胶囊内服联合0.1%他克莫司软膏外用治疗脂溢性皮炎的临床疗效确切,能有效改善皮肤生理指标,调节炎症因子水平,抑制氧化应激反应,同时具有较高的安全性。OBJECTIVE To investigate the clinical efficacy of viaminate capsules for oral administration combined with 0.1%tacrolimus ointment for external use in the treatment of seborrheic dermatitis.METHODS A total of 426 patients with seborrheic dermatitis from Oct.2011 to Oct.2015 in our hospital were selected,and were divided into 2 groups,213 cases in control group treated with 0.1%tacrolimus ointment for external use,and 213 cases in experiment group treated with viaminate capsules for oral administration on the basis of control group.The skin physiological indexes,serum levels of inflammatory cytokines and serum levels of oxidative stress of the two groups were observed and recorded,and the clinical effect and the incidence of adverse reaction were compared after the treatment.RESULTS The effective rate of experiment group was significantly better than that in control group（P〈0.05）.After treatment,the water content of the cuticle in the skin of the two groups increased,and TEWL and the oil content decreased,and the difference was significant（P〈0.001）.After treatment,the levels of serum interleukin-10（IL-10）,catalase（CAT）and superoxide dismutase（SOD）in experiment group were（23.04±3.15）pg/ml,（8.43±1.16）U/ml（14.27±2.03）U/ml,respectively,significantly higher than those in control group（P〈0.001）,and levels of tumor necrosis factor alpha（TNF-α）,interferon gamma（IFN-γ）,and serum malondialdehyde（MDA）in experiment group were（209.05±24.37）pg/ml,（11.02±1.46）pg/ml and（1.26±0.15）pg/ml,respectively which were significantly lower than those in control group（P〈0.001）.CONCLUSION The viaminate capsules for oral administration combined with 0.1% tacrolimus ointment for external use in the treatment of seborrheic dermatitis has curative effect,they can effectively improve the skin physiological indexes,regulate the level of inflammatory factors,inhibit oxidative stress reaction,and have high safety.

关 键 词：脂溢性皮炎 维胺酯胶囊 他克莫司软膏 临床疗效 

分 类 号：R275[医药卫生—中医皮科]