医院获得性肠球菌属细菌感染的分布特征及耐药性分析  

DISTRIBUTION CHARACTERISTICS AND DRUG RESISTANCE OF HOSPITAL-ACQUIRED INFECTIONS DUE TO ENTEROCOCCUS SPP.

作　　者：张洋洋[1,2] 梁丽玲[2] 

机构地区：[1]承德医学院附属医院呼吸内科,河北承德067000 [2]中国人民解放军总医院呼吸内科

出　　处：《承德医学院学报》2018年第2期101-104,共4页Journal of Chengde Medical University

摘　　要：目的:了解医院获得性肠球菌属细菌感染的分布及耐药特点,为临床治疗提供依据。方法:回顾性分析中国人民解放军总医院2013年1月至2015年12月医院获得性肠球菌属细菌感染患者的临床资料。结果:共分离肠球菌属细菌883株。细菌来源科室主要为ICU(292株,33.07%)和肝胆外科(125株,14.16%);标本分布以尿液最多见(347株,39.30%),其次为体液(315株,35.67%)和血标本(202株,22.88%);分离的肠球菌属细菌中屎肠球菌数目最多(596株,67.50%),其次为粪肠球菌(244株,27.63%)。屎肠球菌对氨苄西林、青霉素、链霉素、四环素、红霉素、万古霉素和环丙沙星的耐药率均高于粪肠球菌(P<0.05)。结论:医院获得性肠球菌属细菌感染以屎肠球菌和粪肠球菌为主,屎肠球菌具有更高的耐药率,临床治疗需依据药敏结果合理选用抗菌药物。Objective： To characterize the clinical distribution and drug resistance of hospital-acquired infections due to Enterococcus spp and provide basis for clinical treatment. Methods： The clinical data of hospital-acquired enterococcus infection patients from 2013.1 to 2015.12 in Chinese PLA General Hospital were retrospectively analyzed. Results： A total of 883 strains of Enterococci were isolated in this study. Most of them were isolated from ICU（292 strains, 33.07%） and hepatobiliary surgery department（125 strains, 14.16%）; Urine was the most common sources of these strains（347, 39.30%）, followed by body fluids（315, 35.67%） and blood samples（202, 22.88%）; The top organism was Enterococcus faecium（596, 67.50%）, followed by Enterococcus faecalis（244, 27.63%）. The resistance rates of Enterococcus faecium to ampicillin, penicillin, streptomycin, tetracycline, erythromycin, vancomycin and ciprofloxacin were obviously higher than Enterococcus faecalis（P〈0.05）. Conclusions： Enterococcus faecium and Enterococcus faecalis are the main pathogens in hospitalacquired enterococcus infection, and Enterococcus faecalis has higher resistance rate. It＇s necessary to choose the appropriate antibiotics according to drug susceptibility test in clinical treatment.

关 键 词：肠球菌属 临床分布 耐药性 

分 类 号：R378.1[医药卫生—病原生物学]