成人正常肾脏体素不相干运动磁共振成像的研究  

The study of intravoxel incoherent motion diffusion-weighted imaging of kidneys in healthy adult

作　　者：李标达 陈小燕[2] 鲁可[2] 何建勋[1] 伍筱梅[1] 李新春[1] 蒙秋华[1] 

机构地区：[1]广州医科大学附属第一医院放射科,510120 [2]广州医科大学附属第一医院内分泌科,510120

出　　处：《实用医学影像杂志》2018年第1期6-9,共4页Journal of Practical Medical Imaging

基　　金：广东省科技计划项目(2014A020212353);广东省医学科研基金项目(A2015403)

摘　　要：目的对比不同年龄段健康人的肾皮髓质D值、D~*值、f值差异并初步建立相应年龄段的体素不相干运动(IVIM)指标参考值。方法招募48名30~69岁健康志愿者,男性26名,女性22名,年龄32~69岁,平均(52±13)岁,按10岁年龄梯度分4组进行扫描获得双肾IVIM各参数数值。结果正常肾脏皮质D值、D~*值和f值分别为(1.25±0.18)×10^(-3) mm^2/s、(20.88±9.73)×10^(-3) mm^2/s和(35.55±12.91)%,髓质D值、D~*值和f值分别为(0.96±0.20)×10^(-3)mm^2/s、(13.78±6.38)×10^(-3)mm^2/s和(33.57±0.87)%。肾皮质与髓质的D值、D~*值和f值差异性具有统计学意义(P<0.05);左、右侧肾皮质的D值、D~*值、f值差异无统计学意义,30~69岁范围内,随着年龄的增加,两肾的皮质、髓质D值、D~*值、f值有逐渐轻微增加趋势,到60岁后开始出现轻度下降,经ANOVA检验分析,两肾皮质、髓质的各年龄段D值、D~*值、f值的差异无统计学意义。肾皮质和髓质D值、D~*值、f值与年龄、性别相关程度不高。结论健康人群肾皮质的D值、D~*值、f值较髓质高,与左右、年龄及性别相关程度较低。Objective To compare the D, D ＊ and f value of healthy kidneys in different age groups and estab- lish a reference intravoxel incoherent motion diffusion-weighted imaging（IVIM-DWI） values for each age group. Meth- ods Forty-eight healthy volunteers aged from 30 to 69 were recruited to undergo kidney IVIM-DWI examination, in- cluding 26 males and 22 females, with an average of （52_＋13） years old. The IVIM parameters of kidneys were ob- tained for 4 groups of volunteers which were divided by 10 years age gradient. Results The D, D＊ and f values of the cortical were（1.25＋0.18）x10-3 mm2/s,（20.88_＋9.73）x10-3 mm2/s vs （35.55-＋12.91）%, respectively. And the D, D＊ and f values of the medullary were（0.96-＋0.20）x10~ mm2/s,（13.78＋6.38）x10-3 mm2/s vs （33.57＋0.87）%. The difference of D, D＊ and f value of renal cortex and medulla were statistically significant（P〈0.05）. The D, D＊ and f value of the left and right renal cortex were not significantly different, between age 30 to 59, with the increase of age, the D,D＊ and f value of the cortex and medulla are gradually increasing slightly,and began to decrease slightly after age 60.Us- ing ANOVA test to analyze the differences between the cortex and medullary levels of D, D＊ and f value, the result showed no significant differences for different ages groups.D, D＊ and f value of the kidney of cortex and medulla have low con＇elation with age, gender. Conclusion D, D ＊ and f value of the cortex of normol kidneys were significantly higher than those of the medulla, and low correlation with left or right, age, gender.

关 键 词：磁共振成像 体素不相干运动 年龄因素 性别因素 

分 类 号：R445.2[医药卫生—影像医学与核医学]