丙硫菌唑工业化工艺的开发  

Industrial Process Development of Prothioconazole

作　　者：徐宁[1] 

机构地区：[1]江苏蓝丰生物化工股份有限公司,江苏徐州221400

出　　处：《科技创新与生产力》2018年第1期84-85,89,共3页Sci-tech Innovation and Productivity

摘　　要：以1-氯-1-氯乙酰基环丙烷、2-氯-氯苄为原料,经格式反应制得2-(1-氯环丙基)-3-氯-1-(2-氯苯基)-2-丙醇,经肼解、环合、氧化反应制得丙硫菌唑,产品总收率45%,质量分数大于98%。产物经1H NMR进行了表征。Prothioconazole was synthesized by using 1-chloro-1-chloro-acetyl-cyclopropane and 2-Chlorobenzyl chloride as rawmaterials via Grignard reaction, hydrazinolysis reaction, cyclization and oxidation reaction. The total yield was up to 45%, andthe purity of the products was 98%. The products were determined by 1H NMR.

关 键 词：杀菌剂 丙硫菌唑 1-氯-1-氯乙酰基环丙烷 2-氯-氯苄 

分 类 号：TQ314.218[化学工程—高聚物工业]