浙中农村地区不同人群戊型肝炎病毒感染流行病学调查  

An survey on the status of hepatitis E virus infection among different population groups in rural areas of central Zhejiang province

作　　者：吴红照[1] 缪梓萍[2] 王平平[1] 楼永锦 黄文忠[1] 周燕珍 曹捷 陈奕娟[2] 

机构地区：[1]浙江省浦江县疾病预防控制中心,浙江浦江322200 [2]浙江省疾病预防控制中心,浙江杭州310051

出　　处：《中国农村卫生事业管理》2018年第1期43-46,共4页Chinese Rural Health Service Administration

基　　金：浙江省医药卫生科技计划项目(2016KYB057)

摘　　要：目的:了解浙江中部农村地区戊型病毒性肝炎(戊肝)的人群感染状况,为制定防制措施提供依据。方法:对浦江县2005—2015年戊肝疫情资料进行描述性流行病学分析;采用多阶段随机抽样方法,抽取社区人群、健康体检人群及戊肝有关风险职业人群各250人,31例既往病例及其40例密切接触者,均采用酶联免疫吸附试验(ELISA)法检测血清抗HEV-IgG,比较不同人群抗HEV-IgG阳性率差异。结果:2005—2015年浦江县共报告戊肝病例88例,各年发病率在1.28/10万~3.13/10万之间,占同期病毒性肝炎报告病例数的比例0.70%~10.69%,并呈逐年上升趋势(P<0.01)。报告病例的年龄主要集中在30~59岁,男女性别比为2.67∶1,未见死亡病例、聚集性(暴发)疫情发生。社区和体检人群抗HEV-IgG标化阳性率为45.54%,感染风险较高的职业人群抗HEV-IgG阳性率为63.60%。女性(OR=0.70,95%CI:0.51~0.96)抗HEV-IgG阳性风险较低,年龄增长(OR=1.06,95%CI:1.050~1.07)抗HEV-IgG阳性风险升高。生猪养殖(OR=29.21,95%CI:2.29~371.99)、猪肉贩卖人员(OR=15.44,95%CI:1.47~162.14)抗HEV-IgG阳性的风险高于其他职业,阳性率分别为85.19%、71.43%。既往病例抗HEVIgG阳性率为87.10%,高于密切接触者的52.50%(P<0.05)。结论:浙中浦江县戊肝感染率较高,随年龄增长而上升,基于国家疾病监测信息报告系统的戊肝疫情可能被低估。生猪养殖、猪肉贩卖人员为戊肝感染的高危职业人群。Objective To provide scientific basis for prevention and control of hepatitis E（HE）,we surveyed and ana- lyzed the infection of hepatitis E virus（HEV） in rural areas of central Zhejiang province. Methods The investigation of HE in Pujiang County between 2005 and 2015 was conducted based on National Diseases Reporting Information System. Multi--stage random sampling method being used, 750 people including community population, people having physical examination and HE--related occupational population were selected. Enzyme--linked immunosorbent assay （ELISA）was used to detect anti--HEV--IgG in 31 previous infection cases and 40 close contacts. Comparison was made of the positive rate of anti-- HEV-- IgG among various populations. Results A total of 88 cases were reported between 2005 and 2015. The annual incidences of HE were between 1.28/100,000 and 3.13/100,000, which accounted for 0.70% to 10.69% of the synchronous reported cases of viral hepatitis and the proportion tended to increase year by year（P〈0.01）. Patients＇ ages were mainly 30 to 59 and the male--to--female gender ratio was 2.67 ： 1. There was no death or epidemic outbreak. Standard positive rate of anti--HEV--IgG was 45.54% based on the general population and the professional population had a higher infectious risk with the positive rate of anti--HEV--IgG being 63.60%. Female had a lower infectious risk than male（OR= 0.70,95 % CI： 0.51- 0.96）. The infection rate was positively corre- lated with the age（OR=l. 06,95%CI：1.05-1.07）. Pig farmers（OR=29.21,95%CI：2.29-371.99）and pig sellers （OR= 15.44,95 % CI：1. 47 - 162.14） had a higher infectious rate than other occupations, with the positive rates of anti --HEV--IgG being 85.19% and 71.43 % ,respectively. The positive rate of anti--HEV--IgG in HEV--infected people was 87.10% ,higher than that in close contacts（52.50% ,P^O. 05）. Conclusions Infection rate of HEV is quite high in Pujiang county,which increases with age. It seems that HE epidemic situation bas

关 键 词：戊型病毒性肝炎 血清流行病学 感染率 

分 类 号：R195.4[医药卫生—卫生统计学]