血清唾液酸和超敏C反应蛋白与高血压前期的关系及临床意义  

The relationship between serum sialic acid, high-sensitivity C-reactive protein and prehypertension and their clinical significance

作　　者：李丽红[1] 徐丹蕾[1] 林杨闯[1] 

机构地区：[1]台州市立医院心血管内科,浙江省台州318000

出　　处：《中国基层医药》2018年第1期99-102,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨血清唾液酸（SA）和超敏C反应蛋白（hs-CRP）与高血压前期的关系及临床意义.方法 将160例体检者根据血压值范围分为正常血压组（40例）、高血压前期组（60例）和高血压组（60例）,分别测量所有研究对象的血压、身高和体质量,检测所有对象同一天的血清SA、hs-CRP、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、三酰甘油（TG）和空腹血糖（FBG）水平,采用多元线性回归方法分析血清SA和hs-CRP水平与收缩压（SBP）和舒张压（DBP）的关系.结果 三组间的DBP、SBP、体质量指数（BMI）、SA、hs-CRP、TC、LDL、HDL和FBG水平差异均有统计学意义（F=1 102.039、2 690.642、9.163、116.511、103.634、5.431、4.267、67.352、4.236,均P＜0.05）,其中BMI、SA和hs-CRP水平随着血压升高逐渐上升,而HDL水平逐渐下降（P＜0.05）;高血压组的TC和LDL水平高于正常血压组,高血压前期组与正常血压组的TC、LDL水平差异无统计学意义（P＞0.05）;多元线性回归发现：BMI、SA、hs-CRP和FBG水平均与SBP呈正相关（r=3.66、2.61、3.24、2.39,均P＜0.05）,BMI、SA、hs-CRP和LDL水平均与DBP呈正相关（r=2.20、2.34、3.48、2.28,均P＜0.05）.结论 血清SA与hs-CRP水平均与血压值呈现独立正相关,可作为高血压前期的评估指标.Objective To explore the relationship between serum sialic acid（SA）,high-sensitivity C-reactive protein（hs-CRP） and prehypertension and their clinical significance.Methods According to the blood pressure range,160 residents who received physical examination were divided into three groups：normal group （40 cases）,prehypertension group （60 cases） and hypertension group （60 cases）.The blood pressure,height and weight were measured in all subjects,and the serum levels of SA,hs-CRP,serum total cholesterol （TC）,low density lipoprotein （LDL）,high density lipoprotein（HDL）,triacylglycerol（TG） and fasting plasma glucose（FBG） were detected on the same day.Multiple linear regression was used to investigate the relationship between serum SA and hs-CRP levels and systolic blood pressure（SBP） and diastolic blood pressure（DBP）.Results The levels of DBP,SBP,body mass index（BMI）,SA,hs-CRP,TC,LDL,HDL and FBG among the three groups were statistically significant （F =1 102.039,2 690.642,9.163,116.511,103.634,5.431,4.267,67.352,4.236,all P ＜ 0.05）.The levels of BMI,SA and hs-CRP increased gradually with the increase of blood pressure,while the level of HDL decreased （P ＜ 0.05）.The levels of TC and LDL in the hypertension group were higher than those in the normal blood pressure group,but there were no statistically significant differences in TC and LDL levels between the pre hypertension group and normal blood pressure group （all P ＞ 0.05）.Multiple linear regression showed that the levels of BMI,SA,hs-CRP and FBG were positively correlated with SBP（r =3.66,2.61,3.24,2.39,all P ＜ 0.05）,and the levels of BMI,SA,hs-CRP and LDL were positively correlated with DBP （r =2.20,2.34,3.48,2.28,P all ＜ 0.05）.Conclusion The levels of serum SA and hs-CRP are positively correlated with blood pressure,which can be used as assessment criteria for prehypertension.

关 键 词：高血压前期 唾液酸类 C反应蛋白质 

分 类 号：R544.1[医药卫生—心血管疾病]