阻塞性睡眠呼吸暂停低通气综合征患者脉络膜厚度的变化  

Alteration of choroidal thickness in patients with obstructive sleep apnea hyponea syndrome

作　　者：王静波[1] 刘金伟[2] 张琳[1] 李秀颖 李翔 

机构地区：[1]解放军第309医院眼科,中国北京市100091 [2]解放军第309医院耳鼻喉科,中国北京市100091 [3]陆军防化学院,中国北京市102205

出　　处：《国际眼科杂志》2018年第3期482-485,共4页International Eye Science

基　　金：国家自然科学基金资助项目(No.81100684);首都卫生发展科研专项(No.2011-5007-02);总参军事医学和老年病科研基金项目(No.ZCWS14C19);北京市自然科学基金资助项目(No.7173269)

摘　　要：目的:分析阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者的脉络膜厚度的改变。方法:纳入17例初次诊断为OSAHS的患者和31例健康对照者。利用频域光相干断层扫描仪,采用增强深部成像技术,测量黄斑中心凹及距离中心凹上方、下方、鼻侧和颞侧各2mm部位的脉络膜厚度并进行统计学分析。结果:对照组和OSAHS组中心凹脉络膜厚度分别为323.58±58.63、316.82±46.43μm,差异无统计学意义(t=0.409,P=0.684)。对照组和OSAHS组距中心凹上方2mm脉络膜厚度分别为318.29±56.89、314.29±59.8μm,差异无统计学意义(t=0.229,P=0.820)。对照组和OSAHS组距中心凹下方2mm脉络膜厚度分别为308.42±54.95、291.65±55.37μm,差异无统计学意义(t=1.009,P=0.318)。对照组和OSAHS组距中心凹颞侧2mm脉络膜厚度分别为308.23±54.62、302.76±46.97μm,差异无统计学意义(t=0.347,P=0.730)。对照组和OSAHS组距中心凹鼻侧2mm脉络膜厚度分别为266.23±58.10、277.12±63.99μm,差异无统计学意义(t=-0.599,P=0.552)。分别按睡眠呼吸暂停低通气指数和血氧浓度对OSAHS进行严重程度分级后比较,组内差异均无统计学意义(P>0.05)。结论:与正常人相比,OSAHS患者的脉络膜厚度略有下降(中心凹鼻侧2mm除外),但差异无统计学意义。对于初次诊断为OSAHS的患者,疾病严重程度对脉络膜厚度无影响。AIM:To analyze the choroidal thickness alteration in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).METHODS:Seventeen patients who were diagnosed with OSAHS initially and 31 healthy individuals were enrolled.Enhanced depth imaging choriodal scans were obtained by spectral-domain optical coherence tomography.Choroidal thickness of subfovea,2 mm superior,inferior,nasal and temporal to the fovea were measured and statistically analyzed.RESULTS:Subfoveal choroidal thickness of the control group and the OSAHS group was 323.58±58.63μm and316.82 ± 46.43μm respectively,and the difference was unsignificant(t =0.409,P=0.684).Choroidal thickness at2 mm superior to the fovea of the control group and the OSAHS group was 318.29±56.89μm and 314.29±59.8μm respectively,and the difference was unsignificant(t =0.229,P=0.820).Choroidal thickness at 2 mm inferior to the fovea of the control group and the OSAHS group was308.42±54.95μm and 291.65±55.37μm respectively,and the difference was not significant(t = 1.009,P = 0.318).Choroidal thickness at 2 mm temporal to the fovea of the control group and the OSAHS group was 308.23 ±54.62μm and 302.76 ± 46.97μm respectively,and the difference was not significant(t = 0.347,P = 0.730).Choroidal thickness at 2 mm nasal to the fovea of the control group and the OSAHS group was 266.23 ±58.10μm and 277.12 ± 63.99μm respectively,and the difference was not significant(t =-0.599,P = 0.552).There were no significant differences among subgroups after grading based on the severity of sleep apnea hypopnea index and blood oxygen concentration. CONCLUSION:Compared with healthy individuals,choroidal thickness of patients with OSAHS decreases slightly(except for the location of 2 mm nasal to the fovea),but the alteration is not significant.The severity of OSAHS has no effect on the choroidal thickness for the patients first diagnosis of OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 脉络膜 人体测量术 体层摄影术 光学相干 

分 类 号：R766[医药卫生—耳鼻咽喉科] R771.3[医药卫生—临床医学]