不同剂量地佐辛对丙泊酚靶控输注全身麻醉下BIS和AEPI的影响  

Effect of different dosages of Dezocine on BIS and AEPI under general anesthesia with target-controlled injection of Propofol

作　　者：王馨[1] 

机构地区：[1]河北省承德市中心医院,河北承德067000

出　　处：《中国现代医学杂志》2018年第7期94-98,共5页China Journal of Modern Medicine

摘　　要：目的探究不同剂量地佐辛对丙泊酚靶控输注全身麻醉下脑电双频指数(BIS)和听觉诱发电位指数(AEPI)的影响。方法选取2014年10月-2015年7月于该院进行全身麻醉手术的100例患者。按照随机数字法分为4组,每组25例,所有患者均实施丙泊酚靶控输注,维持麻醉及血流动力学稳定后,分别静脉滴注1μg/kg芬太尼(F组),0.05 mg/kg地佐辛(D1组),0.1 mg/kg地佐辛(D2组),0.15 mg/kg地佐辛(D3组)。记录并比较各组患者全身麻醉诱导前(T)、给药前即刻(T_0)、给药后每隔3 min各时间点(T_1~T_5)的HR、MAP、BIS及AEPI值,最多记录至15 min。结果F组内部各个时间点的HR、MAP、BIS和AEPI值比较,差异无统计学意义(P>0.05)。与F组各个时间点比较,D1组的对应的HR、MAP、BIS和AEPI值升高,D2组的HR和MAP值升高,均差异有统计学意义(P<0.05),而D3组差异无统计学意义(P>0.05)。与T_0时间点比较,D1组的HR、MAP、BIS和AEPI值在各时间点升高,D2组的HR、BIS和AEPI值升高,而D3组的MAP值在T_2~T_5时间点升高,均差异有统计学意义(P<0.05)。结论不同剂量地佐辛对丙泊酚全身麻醉患者的血流动力学参数及麻醉深度有一定影响,剂量为0.15 mg/kg地佐辛可用于全身麻醉,可达有效的麻醉深度,维持术前稳定的血流动力学,值得临床推广应用。Objective To investigate the effect of different dosages of Dezocine on bispectral index （BIS） and auditory-evoked potentials index （AEPI） under general anesthesia with target-controlled injection of Propofol. Methods Totally 100 patients who had operation under general anesthesia in our hospital from October 2014 to July 2015 were divided into 4 groups, with 25 patients in each group. All patients received target-controlled injection of Propofo1. They were then intravenously infused with 0.05, 0.10, 0.15 mg/kg Dezocine （group D1, D2, D3, respectively）, or 1 μg/kg Fentanyl （group F）. Heart rate （HR）, mean arterial blood pressure （MAP）, BIS and AEPI were measured before induction of general anesthesia （T）, immediately before drug administration （T0）, and every 3 min after administration up to 15 min. Results There were no signifcant differences among HR, MAP, BIS or AEPI values at different time points in the group F （P 〉 0.05）. Compared with the values of the group F at each time point, HR, MAP, BIS and AEPI values of the group D1 increased signifcantly, HR and MAP values of the group D2 increased signifcantly （P 〈 0.05）; but there were no signifcant differences between the group D3 and the group F at each time point （P 〉 0.05）. Compared with the T0 values, HR, MAP, BIS and AEPI values of the group D1 increased signifcantly at other time points （P 〈 0.05）, and HR, BIS and AEPI values of the group D2 increased signifcantly, MAP values of the group D3 significantly increased at T2-T5 （P 〈 0.05）. Conclusions Different dosages of Dezocine have certain infuence on hemodynamic parameters and depth of anesthesia in patients undergoing Propofol general anesthesia. General anesthesia can use 0.15 mg/kg Dezocine, which can achieve effective depth of anesthesia and maintain preoperative stable hemodynamics. It is worthy of clinical application.

关 键 词：地佐辛 丙泊酚 脑电双频指数 听觉诱发电位指数 

分 类 号：R614.2[医药卫生—麻醉学]