铜催化的芳烃胺化的研究  

Study on Aromatic Amination Catalyzed by Copper

作　　者：李有桂 郁飞 邓威力 朱成峰 

机构地区：[1]合肥工业大学化学与化工学院,安徽合肥230009

出　　处：《化学世界》2018年第1期28-36,共9页Chemical World

基　　金：国家自然科学青年科学基金(No.21401037)资助项目

摘　　要：在过渡金属铜催化作用下,芳烃与N-氯代酞酰亚胺进行C—N键偶联,实现了芳烃的C—H键的胺化。考察了反应溶剂、催化剂种类、反应时间、反应温度及芳烃结构对反应的影响,确定了较佳的反应条件:0.5mmol N-氯代酞酰亚与2mL芳烃反应,在溴化铜(10mol%)、醋酸碘苯(2mmol)作用下,反应温度为130℃,时间为8h。在此反应条件下,富电子的芳烃反应较好,缺电子的芳烃反应相对较差。C—N coulping between arene and N-chlorophthalimide was realized by copper catalysed C—H activation,affording aminated arene.Reaction conditions including solvent,catalyst,reaction time,and diverse arenes were investigated.The optimized condition is described as follows：0.5 mmol Nchlorophthalimide,2 mL neat arene,and 2 mmol iodobenzene diacetate in the presence of 10 mol% copper acetate at 130 ℃ for 8 h.In general,the electron rich arenes have higher reactivity than electron-poor arenes.

关 键 词：N-氯代酞酰亚胺 芳烃 胺化 溴化铜 醋酸碘苯 

分 类 号：O621.256.4[理学—有机化学]