蛋白肽类药物及其给药途径研究进展  

Research progress of protein peptide drugs and route of administration

作　　者：赵子佳 边学峰[1] 李晶峰[1] 张辉[1] 孙佳明[1] 

机构地区：[1]长春中医药大学,长春130117

出　　处：《吉林中医药》2018年第2期188-190,共3页Jilin Journal of Chinese Medicine

基　　金：国家支撑计划(2012BAI29B00);国家中医药行业专项(2015468002-2)

摘　　要：近年来,蛋白多肽类药物被人们熟知,并不断出现在保健食品中。蛋白多肽在自然界中广泛存在,对疾病的预防与治疗具有参与的作用。本文介绍了对蛋白多肽类药物的认识,包括蛋白多肽的概念、蛋白多肽类药物的特殊性质、多肽类药物生物利用度低的原因以及蛋白多肽类药物非注射剂以外的给药途径,主要可以分为口服途径、透皮途径、黏膜途径、肺部途径四大途径。全面的介绍了蛋白多肽类药物的性质及其给药途径,为其今后的研究和巨大的发展空间奠定了理论基础。In recent years, protein peptide drugs are well known and continue to appear in health food products.Protein polypeptides are widely found in nature and have a role to play in theprevention and treatment of the disease.This article describes the understanding of protein peptides, including the concept of protein peptides, the special properties of protein peptides, the reasons for the low bioavailability of peptides, and the route of administration other than injection of protein peptides oral route, transdermal route, mucosal route, the four pathways of the lungs.A comprehensive introduction of the nature of the protein peptide drugs and its route of administration for its future research and a huge space for development laid the theoretical foundation.

关 键 词：蛋白肽类药物 给药途径 生物利用度 

分 类 号：R282.74[医药卫生—中药学]