甲炎康泰颗粒制备工艺研究  

Study on the preparation technology of Jiayan Kangtai granule

作　　者：石浩霞 徐云玲 解生旭[3] 徐雅娟[3] 李博[1,2] 高佳琪[1,2] 魏颖[1,2] 王东超[1,2] 徐暾海[1,2] 刘铜华[2] 

机构地区：[1]北京中医药大学中药学院,北京100029 [2]中医养生学教育部重点实验室,北京100029 [3]吉林省中医药科学院,长春130021

出　　处：《吉林中医药》2018年第2期201-205,共5页Jilin Journal of Chinese Medicine

基　　金：科学技术部国际科技合作项目(2015DFA30910):中药干预桥本氏甲状腺炎活性筛选技术与组方优化研究;北京中医药大学创新团队-中医药干预糖尿病及其并发症研究团队(2011-CXTD-19)

摘　　要：目的考察甲炎康泰颗粒剂的制备工艺。方法通过正交试验优选提取工艺;以成型性、流动性、溶解性、吸湿性为因素考察颗粒剂的最佳成型工艺。结果夏枯草等药最佳水提工艺为加15倍量水、提取3次、每次2 h,提取液浓缩至相对密度1.05(50~60℃),以70%乙醇沉淀过夜;柴胡等药最佳醇提工艺为加6倍量80%乙醇,提取3次,每次1 h;提取液合并浓缩至干,粉碎,按药辅比1:1~1:1.5加入糊精-乳糖3:1的辅料,加1%阿斯巴甜作为矫味剂,以80%乙醇作润湿剂制粒。结论所得工艺合理可行,所得制剂质量稳定,为甲炎康泰颗粒制粒工艺确定及生产环境控制提供科学依据。Obiective To determine the feasible preparation technology of the Jiayan Kangtai granule. Methods The best molding process of granules was studied by the factors of formability, fluidity, solubility and hygroscopicity. Results Results The optimum water extraction process of Prunella vulgaris was adding 15 times of water, extracting for 3 times, 2 hours each time, the extract was concentrated to a relative density of 1.05（50-60 C） and deposited overnight with 70% ethanol. The best alcohol extraction process of Radix Bupleuri and other drugs was adding 6 times amount of 80% ethanol, extracting 3 times, 1 h each time. The extract was concentrated to dry, crushed, supplemented by 1：1-1：1.5, and added dextrin-lactose 3：1 as excipient, added 1% aspartame as flavoring agent, with 80% ethanol as a wetting agent. The obtained process is reasonable and feasible, and the quality of preparation is stable. It provides scientific basis for the determination of granulation process and production environment control of Jiangyan Kangtai granule.

关 键 词：桥本氏甲状腺炎 复方颗粒 制备工艺 迷迭香酸 柴胡皂苷 

分 类 号：R289.6[医药卫生—方剂学] R283.6[医药卫生—中药学]