艾拉莫德对系统性红斑狼疮模型小鼠的影响  

Influence of Iguratimod on Systemic Lupus Erythematosus Mice

作　　者：王丽平[1] 陈利锋[2] 陈芳[1] 刘琴[1] 张宜[1] 

机构地区：[1]中国人民解放军武汉总医院医学实验科,武汉430070 [2]中国人民解放军武汉总医院中西医结合科,武汉430070

出　　处：《医药导报》2018年第3期289-293,共5页Herald of Medicine

基　　金：湖北省卫生和计划生育委员会医药科研项目(WJ2015MB042)

摘　　要：目的观察艾拉莫德对系统性红斑狼疮(SLE)模型小鼠的预防保护作用。方法将30只雌性BALB/c小鼠随机分为空白对照组、模型对照组、艾拉莫德干预组,每组10只。模型对照组与艾拉莫德干预组同时制备SLE模型。艾拉莫德干预组造模1 d后灌服艾拉莫德6.5 mg·kg-1·d-1,空白对照组与模型对照组正常饲喂。7个月后检测3组小鼠血清自身抗体(抗核抗体、抗ds-DNA抗体、抗RNP/sm抗体)水平,检测尿蛋白量、血清尿素氮、血清肌酐水平及肾脏病理变化。结果艾拉莫德干预组血清抗核抗体、抗ds-DNA抗体、抗RNP/sm抗体水平、尿蛋白阳性率、血清尿素氮、血清肌酐水平均明显低于模型对照组(P<0.05),艾拉莫德干预组肾脏病理变化不明显。结论艾拉莫德能抑制血清抗体产生,改善SLE模型小鼠尿蛋白量、血清尿素、血清肌酐水平,对SLE模型小鼠有预防和保护作用。Objective To investigate the protective effects of iguratimod on systemic lupus erythematosus model mice.Methods A total of 30 female BALB/c mice were randomly divided into blank control group,model control group and iguratimod drug intervention group,with 10 mice in each group.The blank control group was given saline by intraperitoneal injection intervention group.The model control group and iguratimod intervention group were given 0.5 m L of pristane,Then the drug intervention group began to be fed with iguratimod 6.5 mg·kg-1·d-1 from the next day.After 7 months of feeding,the serum autoantibody( anti nuclear antibody,anti ds-DNA antibody,anti RNP/sm antibody),the level of urine protein,serum urea nitrogen and serum creatinine,as well as the renal pathological changes of the three groups were detected and compared. Results Serum anti nuclear antibody,anti ds-DNA antibody and anti RNP/sm antibody levels of the drug intervention group were significantly lower than those of the model control group( P<0.05); Positive rate of urine protein,serum urea nitrogen,serum creatinine of the drug intervention group were significantly lower than those of the model control group( P<0.05).while the renal pathological change of this group is not obvious. Conclusion Iguratimod can inhibit the occurrence of serum antibody in a certain extent,improve the urine protein,serum urea and serum creatinine level of mouse model with systemic lupus erythematosus,which has protective effects on systemic lupus erythematosus.

关 键 词：艾拉莫德 系统性红斑狼疮 降植烷 

分 类 号：R392.33[医药卫生—免疫学] R965[医药卫生—基础医学]