肺部给药系统研究进展  

Research Progress of Pulmonary Drug Delivery System

作　　者：方孟香 张华[1] 曹铭晨 

机构地区：[1]山东中医药大学药学院,济南250355

出　　处：《医药导报》2018年第3期302-305,共4页Herald of Medicine

摘　　要：肺部给药系统是近十几年发展起来的新给药系统,制剂组成和给药方式与一般制剂有明显区别,具有肺局部药物浓度高、无首关效应、药物吸收快等优点,目前成为肺部疾病治疗和促进大分子药物吸收的重要手段。该文通过对肺部给药所用药物、辅料、吸入装置及临床应用进行分析,总结了近年来肺部给药系统的研究进展和特点优势,以期为肺部给药深入研究提供参考。The pulmonary drug delivery system is a new drug delivery system developed in recent decade. Its composition and mode of administration are obviously different from those of the general preparation.The advantages of pulmonary drug delivery system include high local drug concentration,no first pass effect and fast drug absorption.Currently,it has become an important means of treating lung diseases and promoting the drug absorption of macromolecules.The drug categories,excipients,inhalation devices and clinical application of pulmonary drug administration were analysed by literature reviews. Furthermore,the research progress and characteristics of pulmonary drug delivery system in recent years were also summarized,which provide reference for further study of pulmonary drug delivery.

关 键 词：肺部给药系统 载体 吸入装置 

分 类 号：R944.7[医药卫生—药剂学]