恩替卡韦对改善乙型肝炎病毒相关性肾炎肾功能的临床观察  

Clinical observation of entecavir in improving renal function of hepatitis B virus associated glomerulonephritis glomerulonephritis

作　　者：高志芳 陈坚华 潘燕芳 刘金莲 

机构地区：[1]广东省广宁县中医院检验科,526300 [2]广东省广宁县中医院内科,526300

出　　处：《中国实用医药》2018年第3期79-80,共2页China Practical Medicine

摘　　要：目的分析针对乙型肝炎病毒相关性肾炎患者以恩替卡韦用药治疗对其肾功能造成的影响。方法 60例乙型肝炎病毒相关性肾炎患者,参考随机双盲分组法分为参考组和研究组,每组30例。参考组行常规综合治疗;研究组在参考组治疗基础上加恩替卡韦联合治疗。治疗完毕后评估及比较两组治疗效果。结果研究组治疗后总有效率为96.67%,参考组治疗后总有效率为73.33%,研究组治疗后总有效率明显高于参考组,差异具有统计学意义(P<0.05)。结论乙型肝炎病毒相关性肾炎患者以恩替卡韦用药治疗疗效显著,可有效促进患者肝功、肾功的改善,值得借鉴。Objective To analyze the effect of entecavir on renal function of patients with hepatitis B virus associated glomerulonephritis. Methods A total of 60 patients with hepatitis B virus associated glomerulonephritis were divided by random double-blind grouping method into control group and research group, with 30 cases in each group. The control group received routine comprehensive treatment, and the research group received entecavir on the basis of the control group. The treatment effect after treatment was evaluated and compared. Results After treatment, the research group had total effective rate as 96.67%, while the control group had total effective rate as 73.33%. The research group had obviously higher total effective rate after treatment than the control group, and the difference was statistically significant（P〈0.05）. Conclusion Entecavir shows remarkable efficacy for patients with hepatitis B virus associated glomerulonephritis, and can effectively promote the improvement of liver function and renal function. It is worthy of reference.

关 键 词：乙型肝炎病毒相关性肾炎 恩替卡韦 肾功能 疗效 

分 类 号：R512.62[医药卫生—内科学] R692.3[医药卫生—临床医学]