美托洛尔与卡维地洛对高血压患者的血压控制效果及对糖脂代谢的影响比较  

Comparison of the effect of metoprolol and carvedilol on blood pressure control and glycolipid metabolism in hypertension patients

作　　者：李星洪 陈树英 程娟敏 王映伙 莫志香 廖志平 

机构地区：[1]广东省肇庆市端州区人民医院内一科,526040

出　　处：《中国实用医药》2018年第4期69-70,共2页China Practical Medicine

摘　　要：目的比较分析美托洛尔与卡维地洛对高血压患者的血压控制效果及糖脂代谢的影响。方法 162例高血压患者,采取分层随机法分为美托洛尔组与卡维地洛组,每组81例。美托洛尔组采取美托洛尔治疗,卡维地洛组采取卡维地洛治疗。比较两组患者的血压控制效果及糖脂代谢水平。结果两组患者治疗后舒张压、收缩压比较差异均无统计学意义(P>0.05)。卡维地洛组患者空腹血糖、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平分别为(5.65±0.34)、(1.78±0.21)、(5.79±1.00)、(3.49±0.59)mmol/L,均低于美托洛尔组的(6.09±0.41)、(2.21±0.40)、(6.20±1.17)、(3.80±0.68)mmol/L,高密度脂蛋白胆固醇(HDL-C)水平(1.51±0.20)mmol/L高于美托洛尔组的(1.25±0.14)mmol/L,差异均具有统计学意义(P<0.05)。结论卡维地洛在降压的同时对患者糖脂代谢有着正面影响,较美托洛尔更加全面,总体疗效也更有优势,具有较高的临床价值。Objective To compare and analyze the effect of metoprolol and carvedilol on blood pressure control and glycolipid metabolism in hypertension patients. Methods A total of 162 hypertension patients were divided by stratified random method into metoprolol group and carvedilol group, with 81 cases in each group. Metoprolol group was treated with metoprolol, and carvedilol group was treated with carvedilol. Comparison were made on blood pressure control effect and glycolipid metabolism level between two groups. Results Both groups had no statistically significant difference in diastolic blood pressure and systolic blood pressure after treatment （P〉0.05）. Carvedilol group had lower fasting blood glucose, triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C）respectively as （5.65±0.34）, （1.78± 0.21）, （5.79 ± 1.00） and （3.49± 0.59） mmol/L than （6.09 ± 0.41）, （2.21 ± 0.40）, （6.20 ± 1.17） and （3.80 ± 0.68） mmol/L in metoprolol group, and higher high density lipoprotein cholesterol （HDL-C） as （1.51±0.20） mmol/L than （1.25± 0.14） mmol/L in metoprolol group. Their difference was statistically significant （P〈0.05）. Conclusion Carvedilol has a positive effect on glycolipid metabolism while lowering blood pressure in patients with hypertension, and it is more comprehensive than metoDrolol, and its overall efficacv is also more advantageous. It contains high clinical value.

关 键 词：美托洛尔 卡维地洛 高血压 糖脂代谢 

分 类 号：R544.1[医药卫生—心血管疾病]