氟比洛芬酯对内镜逆行胰胆管造影术后胰腺炎的预防作用  

Prevention of pancreatitis by flurbiprofen axetil after endoscopic retrograde cholangiopancreatography

作　　者：陈娜[1] 黄安宁[1] 丁莉莉[1] 刘丽萍[1] 

机构地区：[1]武警北京总队医院麻醉科,100027

出　　处：《武警医学》2017年第12期1213-1215,1219,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的观察氟比洛芬酯对内镜逆行胰胆管造影术(endoscopic retrograde cholangiopancreatography,ERCP)术后胰腺炎的预防作用。方法选择2014-01至2016-12收治的胰胆管疾病行ERCP患者110例,随机均分为氟比洛芬酯组(56例)和对照组(54例)。氟比洛芬酯组麻醉前给予氟比洛芬酯1.5 mg/kg,对照组给予同等剂量生理盐水。术前,术后6 h、12 h抽取患者静脉血,检测血中胰淀粉酶含量,并记录两组患者术后6 h、24 h发生高淀粉酶血症和术后发生胰腺炎的情况。结果两组患者血清胰淀粉酶水平在术前相比差异无统计学意义;术后6 h氟比洛芬酯组血清胰淀粉酶水平(225±67.83)U/L相较对照组(379±112.61)U/L明显降低(P<0.05);术后24 h氟比洛芬酯组血清胰淀粉酶水平减少(127±92.77)U/L相较对照组(186±97.28)U/L降低(P<0.05)。术后6 h氟比洛芬酯组高淀粉酶血症发生率为14.9%(8/56例),低于对照组的35.19%,术后24 h氟比洛芬酯组高淀粉酶血症发生率为5.36%(3/56例),低于对照组的20.37%(P<0.05);两组患者胰腺炎的发生情况氟比洛芬酯组为0,相较对照组的11.1%有统计学差异(P<0.05)。结论氟比洛芬酯可降低ERCP术后血清胰淀粉酶血水平,减少ERCP术后胰腺炎的发生。Objective To investigate the role of flurbiprofen axetil in preventing post-ERCP pancreatitis（ PEP） in patients after endoscopic retrograde cholangiopancreatography（ ERCP）. Methods One hundred and ten ASA Ⅰ or Ⅱ patients who had received ERCP were randomly assigned to the group of intravenous injection of 1. 5 mg/kg flurbiprofen axetil（ flurbiprofen group） and saline alone（ placebo group）. The serum amylase was detected 6 and 24 h after operation,while the incidence of PEP and postoperative hyperamylasemia was compared between the two groups. Results The serum amylase level in flurbiprofen group was significantly lower than that in control group 6 h and 24 h after ERCP [（ 225 ± 67. 83） U/L vs（ 379 ± 112. 61） U/L,（ 127 ± 92. 77） U/L vs（ 186 ±97. 28） U/L]（ P〈0. 05）. 11. 1%（ 6/54） of the patients in control group had PEP compared with 0. 0%（ 0/56） in flurbiprofen group. 35. 19%（ 19/54） of the patients in control group and 14. 9%（ 8/56） in flurbiprofen group had hyperamylasemia 6 h after ERCP,and the incidence of hyperamylasemia was 20. 37%（ 11/54） in control group and 5. 36%（ 3/56） in flurbiprofen group 24 h after ERCP,so there was significant difference between the two groups（ P〈0. 05）. Conclusions Flurbiprofen axetil is an effective,safe and easy method for prevention of PEP.

关 键 词：氟比洛芬酯 内镜逆行胰胆管造影术 高淀粉酶血症 术后胰腺炎 

分 类 号：R657[医药卫生—外科学]