颅脑外伤患者D-二聚体和白细胞参数的相关性  

Correlations between D-dimer and leukocyte levels in patients with traumatic brain injury

作　　者：王新元[1] 周宁[1] 祝峰[1] 张惠[1] 黄勇[2] 许诺[1] 

机构地区：[1]武警江苏总队医院检验科,扬州225003 [2]武警江苏总队医院神经外科,扬州225003

出　　处：《武警医学》2017年第12期1260-1262,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨颅脑外伤患者血浆D-二聚体(D-dimer,D-D)和全血白细胞(white blood cell,WBC)参数的相关性。方法回顾性统计分析医院2014-06至2016-05收治的246例颅脑外伤患者,随机选取35例作为健康对照组,颅脑外伤患者住院后首次检测D-D及血细胞分析,统计D-D异常升高程度和白细胞参数相关性。结果颅脑外伤患者D-D浓度为(8.20±5.93)mg/L,WBC为(12.54±3.59)×109/L,NEU%为(89.97±9.40)%,NEU#为(10.82±3.22)×109/L,明显高于健康对照组的(0.19±0.12)mg/L、(6.15±0.92)×109/L、NEU%为(60.28±9.05)%、NEU#为(4.36±0.11)×109/L,差异均有统计学意义(P<0.01)。D-D升高程度与血细胞参数中WBC、NEU%、NEU#呈正相关(P<0.01),D-D升高程度与血细胞参数中LYM%、LYM#呈负相关(P<0.05)。结论颅脑外伤患者血浆D-D和白细胞计数均高于健康人,而且D-D和白细胞呈正相关性。Objective To explore the significance of increased levels of plasma D-dimer（ D-D） and relevant white blood cell（ WBC） variation for patients with brain trauma. Methods Medical data on two hundred and forty-six cases of patients with craniocerebral trauma was retrospectively analyzed,while another thirty-five healthy people were randomly selected as control. D-D levels and whole blood cells were tested for the first time after hospitalization. Abnormally elevated D-D levels and correlated changes of WBC parameters were statistically analyzed. Results For patients with traumatic brain injury,the D-D concentration was（ 8. 20 ± 5. 93） mg/L,WBC（ 12. 54 ± 3. 59） × 10^9/L,NEU%（ 89. 97 ± 9. 40） % and NEU# was（ 10. 82 ± 3. 22） × 10^9/L,which were significantly higher than in the healthy control group（ 0. 19 ± 0. 12） mg/L,（ 6. 15 ± 0. 92） × 10^9/L,（ 60. 28 ± 9. 05） % and（ 4. 36 ± 0. 11） × 10^9/L（ P〈0. 01） respectively. The degree of elevated D-D was positively correlated with WBC,NEU% and NEU# in blood cell parameters（ P〈0. 01）,but negatively correlated with LYM% and LYM #（ P〈0. 05）. The difference was statistically significant.Conclusions The degree of D-D and WBC of patients are higher than those of healthy people. The degree of elevated D-D is positively correlated with WBC for patients with brain trauma.

关 键 词：颅脑外伤 D-二聚体 白细胞参数 相关性 

分 类 号：R641[医药卫生—外科学] R446.11[医药卫生—临床医学]