Synthesis of Quinoline and 1,2,3,4-Tetrahydroquinoline Derivatives from Substituted o-Nitrotoluenes via Cesium-promoted [2＋4] Cycloaddition  

作　　者：Weijie Guo Maocong Yi Jianhui Wang Guiyan Liu 

机构地区：[1]Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China [2]Tianjin Key Laboratory of Structure and Performance for Functional Molecules Key Laboratory ofInorganic-Organic Hybrid Functional Material Chemistry, Ministry of Education College of Chemistry, Tianjin Normal University, Tianjin 300387, China

出　　处：《Chinese Journal of Chemistry》2017年第10期1569-1574,共6页中国化学（英文版）

摘　　要：An atom economical highly efficient method has been developed for the synthesis of quinoline and 1,2,3,4-tetra- hydroquinoline derivatives from o-nitrotoluenes bearing electron-withdrawing groups and olefins （acrylic esters, acrylonitriles, and methyl acrylates） via a base-catalyzed [2＋4] cycloaddition. This simple, rapid, and environment- friendly method provides a practical pathway for the synthesis of quinoline and 1,2,3,4-tetrahydroquinoline derivatives. The starting materials are readily available and 37 products were obtained in good to excellent yields.An atom economical highly efficient method has been developed for the synthesis of quinoline and 1,2,3,4-tetra- hydroquinoline derivatives from o-nitrotoluenes bearing electron-withdrawing groups and olefins （acrylic esters, acrylonitriles, and methyl acrylates） via a base-catalyzed [2＋4] cycloaddition. This simple, rapid, and environment- friendly method provides a practical pathway for the synthesis of quinoline and 1,2,3,4-tetrahydroquinoline derivatives. The starting materials are readily available and 37 products were obtained in good to excellent yields.

关 键 词：QUINOLINE 1 2 3 4-tetrahydroquinoline CESIUM CYCLOADDITION 

分 类 号：TQ246.12[化学工程—有机化工] O636.1[理学—高分子化学]