A Facile Synthesis of Benzo[h]quinolines via Silica-TsOH-P2O5 Promoted Condensation of 1-Naphthylamines with 1,3-Diketones under Solvent Free Conditions  

作　　者：Chuanlei Zhu Ruiqiang Guo Zhe Sheng Yanzhe Li Changhu Chu 

机构地区：[1]School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China

出　　处：《Chinese Journal of Chemistry》2017年第10期1595-1600,共6页中国化学（英文版）

摘　　要：A facile synthesis of benzo[h]quinolines has been developed via improved Combes reaction. A combination of silica gel, p-toluenesulfonic acid and phosphorus pentoxide was utilized to promote the condensation of 1-naphthylamines with 1,3-diketones under solvent free conditions. In this case, silica gel was used as reaction media, p-toluenesulfonic acid and phosphorus pentoxide were acted as catalyst and dehydrating agent, respectively.A facile synthesis of benzo[h]quinolines has been developed via improved Combes reaction. A combination of silica gel, p-toluenesulfonic acid and phosphorus pentoxide was utilized to promote the condensation of 1-naphthylamines with 1,3-diketones under solvent free conditions. In this case, silica gel was used as reaction media, p-toluenesulfonic acid and phosphorus pentoxide were acted as catalyst and dehydrating agent, respectively.

关 键 词：silica-TsOH-P2O5 benzo[h]quinoline catalysis synthesis solvent free 

分 类 号：TQ630.44[化学工程—精细化工] P434[天文地球—大气科学及气象学]