抗肿瘤药物的眼部不良反应  

The ocular adverse reactions of chemotherapy drugs

作　　者：吴娅莉 余敏斌[1] 

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室,广州510060

出　　处：《国际眼科纵览》2017年第6期424-430,共7页International Review of Ophthalmology

基　　金：广州市科技计划项目科技惠民专项（2014Y2-00172）

摘　　要：随着抗肿瘤药物研究小断发展，各类化疗药物在显著延长患者生仔期的同时也伴随着大量不良反应发生。眼部不良反应包括视力下降、干眼、结膜炎、角膜炎等。常见引起眼部不良反廊的化疗药物有烷化剂、抗代谢药物、有丝分裂抑制剂和分子靶向治疗药物等。化疗药物引起的眼部不良反应通常是不呵逆转的，因此临床医生必须意识到潜在的视力损伤，早期诊断和干预，适当减量或问歇给药可能有助于减轻不良反应的严重程度和持续时间，将有助于改善患者生存质量。With the continuous development of anti-cancer drug research, kinds of chemotherapy drugs significantly prolong the survival of patients, but also accompanied by a large number of adverse reac- tions. Eye adverse reactions, including decreased vision, dry eyes, conjunctivitis, keratitis. Common chem- otherapy drugs that can cause ocular adverse reactions are alkylating agents, antimetabolites, mitotic inhibi- tors and molecular targeted therapies. Ocular adverse effects caused by chemotherapeutic drugs are often ir- reversible, so clinicians must be aware of potential visual impairment. Early diagnosis and intervention, dose reduction or discontinuation of incriminated drugs may help in reducing severity and duration of side effects, which will help to improve the life quality of patients.

关 键 词：化学治疗 眼部 不良反应 

分 类 号：R979.1[医药卫生—药品]