上皮间质转化的表观遗传调控  

Epigenetic regulation of epithelial-mesenchymal transition

作　　者：李文清[1] 侯劲松[1] 

机构地区：[1]中山大学光华口腔医学院附属口腔医院口腔颌面外科广东省口腔医学重点实验室,广州510055

出　　处：《国际肿瘤学杂志》2017年第12期918-921,共4页Journal of International Oncology

基　　金：国家自然科学基金（81572660）;广东省自然科学基金（2015A030313034）

摘　　要：E-钙黏蛋白（E-cadherin）表达丧失是上皮间质转化（EMT）的重要标志，许多EMT转录因子结合到E-cadherin启动子区下调其表达，从而调节EMT。表观遗传调控包括DNA甲基化、组蛋白修饰、微小RNA，均参与EMT相关基因表达调控。研究表明，EMT转录因子协同表观遗传调控因子参与E-cadherin表达。靶向EMT表观调控代表着肿瘤新的治疗方向。The hallmark of epithelial-mesenchymal transition （EMT） is the loss of E-cadherin. The downregulation of E-cadherin can he mediated by its transcriptional repression through the binding of EMT tran- scription factors to the E-eadherin promoter. Epigenetie mechanisms including DNA methylation, histone code and microRNAs are involved in the regulation of EMT-related genes. Studies have shown that EMT transcription factors can cooperate with several epigenetic modifiers to participate in the expression of E-cadherin. Targeting epigenetie regulation of EMT represents a new promising therapeutic direction.

关 键 词：DNA甲基化 微RNAS 组蛋白修饰 上皮间质转化 

分 类 号：R730.2[医药卫生—肿瘤]