妊娠早期预测子痫前期的血清生物学指标研究进展  

Advances of serum biological markers for predicting preeclampsia in early pregnancy

作　　者：曲光瑾[1] 李悦[1] 罗善顺[1] 张云明[1] 黄明莉[1] 胡菲菲[1] 曹荣祎[1] 王鸿慧[1] 韩辉[1] 

机构地区：[1]哈尔滨医科大学附属第一医院干部病房,黑龙江哈尔滨150001

出　　处：《中国妇幼健康研究》2017年第12期1777-1779,共3页Chinese Journal of Woman and Child Health Research

基　　金：国家自然科学基金资助项目(81401203)

摘　　要：子痫前期是母婴围生期严重影响母胎生命安全的疾病,其发病率占妊娠妇女的5%~8%。目前针对子痫前期的早期预测及检验指标的研究很多,早期筛查策略主要以病史及临床检查(如体质量指数、平均动脉压、子宫动脉彩超等)为基础进行风险评估,尚无一种单一的生物学指标有足够的临床证据支持子痫前期的早期预测。该文对近年来国内外对子痫前期在妊娠早期时的血清生物学指标的研究热点进行总结,分析子痫前期的相关指标研究(胎盘功能、胎儿因素、血管形成因素)、代谢组学、RNA组学、hcg及基因多态性等方面的研究进展,为早期预测子痫前期的发生提供理论依据。Preeclampsia is maternal and perinatal disease seriously affecting life safety.The incidence of it is about 5%-8% in pregnant women.At present there are a lot of researches and testing indicators for early prediction of preeclampsia.But early screening strategy is mainly based on the history and clinical examination（such as BMI,mean arterial pressure,uterine artery color Doppler ultrasound）for risk assessment.There is not a single biological indicator for early prediction of preeclampsia with enough clinical evidence.Now there are a lot of researches and testing indicators for early prediction of preeclampsia.This article reviewed research hotspot of serum markers predicting preeclampsia in early pregnancy,and analyzed the advances in related indicators of preeclampsia（placental function,fetal factors,angiogenesis factors）,metabonomics,RNA omics,hcg and gene polymorphism for providing some theoretical evidence for early predicting preeclampsia.

关 键 词：子痫前期 血清 早期预测 组学 

分 类 号：R714.24[医药卫生—妇产科学]