不同麻醉方法对手术后小儿Toll样受体4表达及血清S100β蛋白水平的影响  

Effects of different anesthesia methods on postoperative TLR4 expression and serum S100β protein level in children

作　　者：朱焱林[1] 严三萍[1] 汪东军[1] 林灿 刘明基[1] 蒋亚欧 

机构地区：[1]江苏省靖江市人民医院麻醉科,江苏靖江214500

出　　处：《实用临床医药杂志》2018年第5期59-61,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨不同麻醉方法对小儿术后Toll样受体4(TLR4)表达及血清S100β蛋白水平的影响。方法择期小儿外科手术患儿122例随机分成2组,对照组为氯胺酮静脉麻醉组,观察组为七氟烷吸入麻醉组。观察术后TLR4表达、血清S100β蛋白水平表达变化及麻醉不良反应。结果麻醉期间,观察组体动、精神症状发生率显著低于对照组(P<0.05)。观察组术后2 h、24 h血清S100β蛋白水平显著低于对照组(P<0.05)。与术前相比,观察组切皮时、术后2 h及24 h的TLR4的表达无显著差异(P>0.05);对照组切皮时、术后2 h及24 h的TLR4显著低于观察组及术前水平(P<0.05)。结论对手术患儿采取七氟烷吸入麻醉方案的不良反应较少。Objective To explore the effects of different anesthesia methods on postoperative TLR4 expression and the level of serum S10015 protein in children. Methods Totally 122 children with elective surgery were randomly divided into two groups. The control group was treated with ket- amine intravenous anesthesia, while the observation group was treated with inhalation anesthesia with sevoflurane. Expression of TLR4, the level of serum S100β protein and the adverse reactions of anes- thesia were observed. Results During the period of anesthesia, the incidence rates of physical and mental symptoms in the observation group were significantly lower than the control group （ P 〈 0.05 ）. The levels of serum S10015 protein at 2 h and 24 h after operation in the observation group were signif- icantly lower than those in the control group （ P 〈 0.05 ）. Compared with those before operation, there was no significant difference in the expression of TLR4 at the time of skin incision, 2 h and 24 h after operation （P 〉 0.05 ）. The expressions of TLR4 at the time points of after skin incision, 2 h and 24 h after operation in the control group were significantly lower than those before operation and the observation group （ P 〈 0.05 ）. Conclusion The sevoflurane inhalation anesthesia can reduce the adverse reactions of anesthesia in children with surgery.

关 键 词：麻醉方法 TOLL样受体4 S100Β蛋白 不良反应 氯胺酮 七氟烷 

分 类 号：R614[医药卫生—麻醉学]