川芎嗪注射液治疗小儿重症肺炎疗效及对痰液炎症因子影响  

Clinical efficacy of Chuanxiongqin injection and the influence on inflammatory factors in sputum of children with severe pneumonia

作　　者：张莉娜[1] 潘继波 邱丽丽 

机构地区：[1]胜利油田中心医院,东营257034 [2]中国石化集团胜利石油管理局胜利医院,东营257000

出　　处：《中药药理与临床》2017年第5期180-183,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:分析川芎嗪注射液对小儿重症肺炎的疗效及对痰液炎症因子影响。方法:我院儿内科2015年9月~2017年2月期间收治的114例重症肺炎患儿作为对象进行分析,根据入院顺序抽取偶数组为对照组,该组给予常规对症方案治疗,奇数组为观察组,该组在常规治疗基础上加用川芎嗪注射液,分析川芎嗪注射液对患儿疗效的影响。结果:(1)在总有效率上,观察组为96.49%,明显高于对照组80.70%。观察组死亡率5.26%和对照组8.77%比,差异无统计学意义。观察组体温恢复正常、咳嗽消失、呼吸困难消失和肺啰音消失时间分别为(3.19±0.69、6.49±1.27、4.29±1.01、5.86±1.24)d,均明显短于对照组(4.58±1.02、8.30±1.59、6.13±1.15、8.06±1.53)d。(3)治疗后,观察组MMF、PEF、RR分别为(1.69±0.17L/s、2.08±0.21L/s、30.19±3.81次/min),均明显优于对照组(1.24±0.14L/s、1.61±0.16L/s、35.90±4.28次/min)。(4)治疗后,观察组痰液中TNF-ɑ、IL-10水平分别为(22.08±3.51、26.19±5.20)pg/ml,均明显低于对照组(27.69±3.73、32.08±5.42)pg/ml。(5)观察组发生7.02%的不良反应,和对照组8.77%比,差异无统计学意义。结论:川芎嗪注射液可用于小儿重症肺炎的联合用药,其可加快控制患儿炎症,改善肺功能,提高治疗效果。Objective： To analyse the clinical efficacy of Chuanxiongqin injection and its influence on inflammatory factors in sputum on children with severe pneumonia. Methods： 114 children with severe pneumonia from September 2015 to February 2017 were grouped into two groups.Patients in two groups were treated with routine symptomatic treatment and those in the observation group were additionally treated with Chuanxiongqin injection,then the effect of Chuanxiongqin was observed. Results： The total efficiency in the observation group was 96. 49%,higher than that in the control group with 80. 70%（P〈0. 05）. The mortality rate in the observation group was 5. 26%,compared with the control group with 8. 77%,P〈0. 05. The time of body temperature decreased to the normal degree,cough disappearing,dyspnea disappearing and lung rales disappearing in the observation group were（3. 19 ± 0. 69,6. 49 ± 1. 27,4. 29 ± 1. 01,5. 86 ± 1. 24） d,shorter than those in the control group（4. 58 ± 1. 02,8. 30 ± 1. 59,6. 13 ± 1. 15,8. 06 ± 1. 53） d（all P〈0. 05）.（3）MMF,PEF,RR in the observation group were（1. 69 ±0. 17 L/s,2. 08 ± 0. 21 L/s,30. 19 ± 3. 81 times/min）,better than those in the control group（1. 24 ± 0. 14 L/s,1. 61 ± 0. 16 L/s,35. 90 ± 4. 28 times/min）（all P〈0. 05）.（4）After the treatment,levels of TNF-ɑ and IL-10 in sputum in the observation group were（22. 08 ± 3. 51,26. 19 ±5. 20） pg/ml,lower than those in the control group（27. 69 ± 3. 73,32. 08 ± 5. 42） pg/ml（all P〈0. 05）.（5）7. 02% adverse reactions occurred in the observation group,compared with the control group（8. 77%）,P〉0. 05. Conclusion： Chuanxiongqin injection can be used in the treatment of severe pneumonia in children and it can accelerate the inflammation,improve lung function and improve the therapeutic effect.

关 键 词：川芎嗪注射液 小儿 重症肺炎 痰液炎症 

分 类 号：R272[医药卫生—中医儿科学]