缬草双环氧木脂素类化学成分研究  

Chemical Components of Bisepoxylignans of Valeriana officinalis

作　　者：左月明[1] 严欢[1] 张忠立[1] 徐元利[1] 王亚芳 

机构地区：[1]江西中医药大学药学院,江西南昌330004

出　　处：《中药材》2017年第7期1607-1610,共4页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(81460596)

摘　　要：目的:研究缬草的双环氧木脂素类化学成分。方法:采用各种柱色谱方法分离纯化,通过理化常数测定和光谱分析鉴定双环氧木脂素类化合物的结构。结果:从缬草20%和70%乙醇洗脱部位中分离并鉴定了10个双环氧木脂素类化合物,分别为:(+)-松脂素-4,4'-O-β-D-二吡喃葡萄糖苷(1)、3'-去甲基-松脂素-4,4'-O-β-D-二吡喃葡萄糖苷(2)、(+)-松脂素-4-O-β-D-吡喃葡萄糖苷(3)、5'-甲氧基-松脂素-4,4'-O-β-D-二吡喃葡萄糖苷(4)、8,8'-二羟基-松脂素-4-O-β-D-吡喃葡萄糖苷(5)、8,8'-二羟基-松脂素-8-O-β-D-吡喃葡萄糖苷(6)、8-羟基-松脂素-4-O-β-D-吡喃葡萄糖苷(7)、8'-羟基-松脂素-4-O-β-D-吡喃葡萄糖苷(8)、8,8'-二羟基-松脂素(9)、4,4'-二去甲基松伯醇-3'-去甲基-8,8'-二羟基-松脂素(10)。结论:其中,化合物2、4、6、10为首次从该属中分离得到,化合物2、4、6、7、9、10为首次从该植物中分离得到。Objective： To investigate the chemical components of bisepoxylignans of Valeriana officinalis.Methods： Various column chromatography were used in the isolation and purification,physiochemical constant determination and spectral analysis were adopted to determine the chemical structures of bisepoxylignans.Results： Ten bisepoxylignans were isolated from the 20% and 70% ethanol elution parts of Valeriana officinalis as（＋）-pinoresinol-4,4＇-O-β-D-di-glucopyranoside（1）,3＇-demethyl-pinoresinol-4,4＇-O-β-D-di-glucopyranoside（2）,（＋）-pinoresinol-4-O-β-D-glucopyranoside（3）,5＇-methoxyl-pinoresinol-4,4＇-O-β-D-di-glucopyranoside（4）,8,8＇-dihydroxyl-prinsepiol-4-O-β-D-glucopyranoside（5）,8,8＇-dihydroxyl-prinsepiol-8-O-β-D-glucopyranoside（6）,8-hydroxyl-prinsepiol-4-O-β-D-glucopyranoside（7）,8＇-hydroxyl-prinsepiol-4-O-β-D-glucopyranoside（8）,8,8＇-dihydroxyl-prinsepiol（9） and 4,4＇-didemethylconiferolyl-3＇-demethyl-8,8＇-dihydroxyl-prinsepiol（10）.Conclusion： Compounds 2,4,6,10 are isolated from Valeriana genus for the first time,compounds 2,4,6,7,9,10 are isolated from this plant for the first time.

关 键 词：缬草 双环氧木脂素类 化学成分 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]