头花蓼全草正丁醇部位的烷基糖苷类化学成分研究  

Alkyl Glycosides from n-Butanol Fraction of Polygonum capitatum Herbs

作　　者：杨阳 王志鹏[2] 高守红[2] 吴志军[2] 

机构地区：[1]徐州医科大学附属淮海医院/中国人民解放军第九七医院药剂科,江苏徐州221004 [2]中国人民解放军第二军医大学附属长征医院药学部,上海200003

出　　处：《中药材》2017年第8期1846-1848,共3页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(81274032);徐州市医学青年后备人才工程资助项目(徐卫科教[2015]7号文件);第九七医院院内科研课题经费资助项目(YN2013009)

摘　　要：目的:研究头花蓼全草正丁醇部位的烷基糖苷类化学成分。方法:采用反复Sephadex LH-20、反相硅胶柱层析及MCI凝胶柱色谱方法分离纯化化学成分,通过与文献报道的波谱数据对比分析进行化合物的结构鉴定。结果:从头花蓼全草正丁醇部位中分离鉴定了7个烷基糖苷类化合物,分别为:1-O-丁基-β-D-吡喃葡萄糖苷(1)、1-O-丁基-α-D-呋喃葡萄糖苷(2)、1-O-丁基-β-D-呋喃葡萄糖苷(3)、2-O-丁基-β-D-吡喃果糖苷(4)、3-O-丁基-β-D-吡喃果糖苷(5)、2-O-丁基-α-D-呋喃果糖苷(6)、2-O-丁基-β-D-呋喃果糖苷(7)。结论:其中,化合物1~5为首次从该植物中分离得到,化合物1~3和5为首次从蓼属植物中分离得到,化合物1~3和5为首次从蓼科植物中分离得到。Objective： To study alkyl glycosides from n-butanol fraction of Polygonum capitatum herbs. Methods： Chemical constituents were repeatedly isolated and purified by Sephadex LH-20,ODS C18 and MCI gel column chromatography. Their structures were identified by spectral analysis,which were compared with spectral data reported in the literatures. Results： Seven compounds were isolated from n-butanol fraction of the whole plant,and identified as 1-O-butyl-β-D-glucopyranoside（ 1）,1-O-butyl-α-D-glucofuranoside（ 2）,1-O-butyl-β-D-glucofuranoside（ 3）,2-O-butyl-β-D-fructopyranoside（ 4）,3-O-butyl-β-D-fructopyranoside（ 5）,2-O-butyl-α-D-fructofuranoside（ 6） and 2-O-butyl-β-D-fructofuranoside（ 7）. Conclusion： Compounds 1 ~ 5 are obtained from this plant for the first time,compounds1 ~ 3 and 5 are obtained from Polygonum genus for the first time,compounds 1 ~ 3 and 5 are obtained from Polygonaceae family for the first time.

关 键 词：头花蓼 化学成分 烷基糖苷 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]