不同年龄组男性人群甲状腺功能与骨密度及骨微结构的相关性  

Correlation of thyroid function with bone mineral density and bone microstructure in men of different age groups

作　　者：盛云露[1] 马丹[2] 王思婷[1] 丁国宪[1] 祁寒梅[1] 

机构地区：[1]南京医科大学第一附属医院老年医学科,江苏南京210029 [2]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2017年第12期1577-1582,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金青年基金(81400856)

摘　　要：目的 :研究不同年龄组男性人群中正常范围内的甲状腺功能与骨密度及新型骨微结构评估指标骨小梁评分的相关性。方法:191例<60岁和97例≥60岁且符合入选标准的男性体检者,检测一般生化指标、游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free thyroxine,FT4)、促甲状腺素(thyroid stimulating hormone,TSH),采用双能X线骨密度仪检测股骨颈、总髋部及腰椎骨密度(bone mineral density,BMD),运用TBS i Nsight软件分析得出骨小梁评分(trabecular bone score,TBS)。结果 :在两个年龄组,TBS与各部位BMD均呈正相关;在青中年男性人群中,FT3水平不仅与总髋部BMD、腰椎BMD呈负相关,而且与腰椎TBS呈负相关,且较BMD更明显;在老年男性人群中,股骨颈BMD、总髋部BMD及TBS与年龄呈负相关,而与甲状腺功能无相关性。结论:TBS和各部位BMD有良好的相关性;在甲状腺功能正常的青中年男性人群中,正常上限的FT3可能导致骨量下降和骨微结构破坏。而在甲状腺功能正常的老年男性人群中,较之于甲状腺功能,年龄对骨密度及骨微结构的不利影响更大。Objective： To investigate the correlation between thyroid function within the normal range and bone mineral density as well as trabecular bone score in men of different age groups.Methods： Total of 191 men 60 years old as well as 97 men ≥60 years old,conformed to the inclusion criteria,were recruited.Free triiodothyronine（FT3）,free thyroxine（FT4）,thyroid stimulating hormone（TSH） and ordinary biochemistry indexes were measured.Dual energy X-ray absorptiometry（DXA） was used to measure bone mineral density（BMD） of femoral neck,total hip and lumbar spine.Trabecular bone score（TBS） was calculated with TBS i Nsightsoftware.Results：In both groups,TBS was positively correlated with BMD of each part tested.FT3 was negatively related with total hip BMD,lumbar spine BMD and TBS in young and middle-aged men.However,in elderly men,femoral neck BMD,total hip BMD and TBS were negatively related to age,which were not associated with thyroid function.Conclusion： There is a good correlation between TBS and BMD.Elevated FT3 level within the normal range was associated with bone loss and bone microstructure destruction in young and middle-aged men.In elderly men with normal thyroid function,age may have more adverse effect on bone mineral density and bone microstructure compared to thyroid function.

关 键 词：甲状腺功能 骨密度 骨微结构 不同年龄组 

分 类 号：R581[医药卫生—内分泌]