桑枝多糖对糖尿病小鼠肾脏的保护作用  

The Protective Effect of Mulberry Polysaccharide on Kidney in Diabetic Mice

作　　者：李永智[1] 

机构地区：[1]中国医科大学附属第四医院泌尿外科,辽宁沈阳110032

出　　处：《中国中医药现代远程教育》2018年第3期83-84,共2页Chinese Medicine Modern Distance Education of China

基　　金：辽宁省教育厅科学研究【No.L2015576】

摘　　要：目的探讨桑枝多糖对糖尿病小鼠肾脏的保护作用机制。方法小鼠70只,注入链尿佐菌素(STZ)造模,随机分为对照组、模型组、缬沙坦组、桑枝多糖组各15只,6周后,测定小鼠血清中FBG、IL-6、TNF-α含量,肾脏组织内MnSO D、MDA、GSH-Px含量。结果与模型组比较,对照组、缬沙坦组、桑枝多糖组FBG、IL-6、TN F-α明显降低,差异有统计学意义(P<0.01)。与缬沙坦组比较,桑枝多糖组IL-6、TNF-α明显降低,差异有统计学意义(P<0.01)。与模型组比较,对照组、缬沙坦组、桑枝多糖组Mn-SOD、GSH-Px明显增高,MDA明显降低,差异有统计学意义(P<0.01)。与缬沙坦组比较,桑枝多糖组Mn-SOD、GSH-Px明显增高,MDA明显降低,差异有统计学意义(P<0.01)。结论桑枝多糖能够减少糖尿病小鼠血清中炎症因子,减少肾组织过氧化反应,起到保护肾脏的作用。Objective To discuss the mechanism of the protective effect of mulberry polysaccharide on kidney in diabetic mice.Methods 70 mice, injection chain urine with cephalosporins（ STZ） building, were randomly divided into control group, model group, valsartan, ramulus mori polysaccharide group, and each had 15 mice. Only six weeks later, the determination of FBG, IL-6 in mice serum, the content of TNF-α, the content of Mn-SOD, MDA and GSH-Px in renal tissue was detected. Results Comparing with the model group, the control group, valsartan group, mulberry polysaccharide group FBG, IL-6 and TNF-α were significantly reduced,and the difference was statistically significant. Comparing with valsartan group, IL-6 and TNF-α of mulberry polysaccharide group decreased significantly, and the difference was statistically significant. Comparing with the model group, the Mn-SOD and GSH-Px of the control group, valsartan group and mulberry polysaccharide group increased significantly, and the MDA significantly decreased,and the difference was statistically significant P 0.01. Comparing with valsartan group, Mn-SOD and GSH-Px of sang-polysaccharide group significantly increased, and the MDA significantly decreased, and the difference was statistically significant P 0.01.Conclusion Mulberry polysaccharide can reduce the inflammatory factors in the serum of diabetic mice, reduce the peroxidation reaction of the kidney and protect the function of the kidney.

关 键 词：桑枝多糖 糖尿病 肾脏 消渴 

分 类 号：R285.5[医药卫生—中药学]