五水头孢唑林钠联合左氧氟沙星治疗急性泌尿系感染的疗效及安全性评价  

The clinical efficacy and safety evaluation of cefazolin sodium combined with levofloxacin for acute urinary tract infection

作　　者：李雪峰[1] 

机构地区：[1]枣阳市第一人民医院泌尿外科,湖北枣阳441200

出　　处：《国际泌尿系统杂志》2018年第1期109-113,共5页International Journal of Urology and Nephrology

摘　　要：目的 探索急性泌尿系感染患者实施五水头孢唑林钠联合左氧氟沙星治疗的临床效果以及安全性,促进临床更合理的选择和应用药物.方法 选取本院收治的100例急性泌尿系感染患者的临床资料,收治时间段为2016年1月至2016年6月间;按照随机抽签分为观察组50例,常规组50例.常规组在基础治疗基础上实施五水头孢唑林钠治疗,观察组在常规组基础上采取五水头孢唑林钠和左氧氟沙星联合治疗.对两组的临床治疗效果、细菌清除率疗效、血清及尿液IL-8表达水平、不良反应进行评价.结果 两组患者治疗后的症状评分相比 治疗前明显下降（P＜0.05）,观察组的症状评分、细菌清除率以及IL-8表达下降更明显;观察组总有效率97.6％ （41/42）,常规组77.8％ （35/45）,差异具有统计学意义（X2=7.743,P=0.0208）;常规组细菌清除率为75.6％（34/45）,而观察组细菌清除率为95.23％（40/45）,观察组治疗方式显著优于常规组（X2=6.622,P=0.0365）;观察组不反应发生率2.3％ （1/42）;常规组不良反应发生率8.89％ （4/45）,差异无统计学意义（x2=1.699,P=0.4277）.结论 急性泌尿系感染患者经头孢唑林钠联合左氧氟沙星联合治疗,临床症状和治疗效果等级改善效果更佳,能够降低炎症水平,下调IL-8的表达水平,不良反应发生率低,值得临床推广.Objective To investigate the clinical efficacy and safety of cefazolin sodium combined with levofloxacin for acute urinary tract infection.Methods A total of 100 patients with acute urinary tract infection were selected and randomly divided into observation group （n =50） and the conventional group （n =50）.Patients in conventional group received cefazolin sodium pentahydrate treatment on the basic treatment and patients in observation group underwent levofloxacin treatment on the basis of the control group,the effect of patients in two groups,cure efficiency,WBC number,IL-8 were compared.Results The treatment symptom score of two groups after treatment decreased significantly （x2 =7.743,P =0.0208）,and the total efficiency rate of observation group was 97.6％ （41/42）and the total efficiency of conventional group was 77.8％ （35/45）.The bacteria clearance of two groups was also significantly different （x2 =6.622,P =0.0365）.The clearance rate of observation group was 95.23％ （40/45）,while the clearance rate of conventional group was 77.8％ （35/45）.The IL-8 of two groups after treatment decreased significantly and the observation group significantly declined compared with conventional group （P ＜ 0.05）.The effect level of treatment group was superior to the conventional group （P ＜ 0.01）,moreover,the rate of adverse reactions in the observation group was 2.3％ （1/42）and the rate of adverse reactions in the convention group was 8.89％ （4/45）.Conclusions Patients with acute urinary tract infection received cefazolin sodium combined with levofloxacin treatment can improve treatment effect significantly and reduce levels of inflammatory factors IL-8.So it is worth to clinical application.

关 键 词：泌尿道感染 头孢唑林 氧氟沙星 

分 类 号：R691.3[医药卫生—泌尿科学]