Er：YAG点阵激光联合10％ 5-氨基酮戊酸光动力治疗顽固性扁平疣的疗效  

Combined ablative fractional Er ： YAG laser and 10 % ALA-PDT in treatment of refractory verruca plana

作　　者：唐莉[1] 林琳[1] 肖艳[1] 夏爱爱[1] 杨希川[1] 宋志强[1] 尹锐[1] 

机构地区：[1]第三军医大学西南医院皮肤科,重庆400038

出　　处：《中华医学美学美容杂志》2017年第6期393-395,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的 探讨Er∶YAG（2940 nm）点阵激光联合10％5-氨基酮戊酸（5-aminolevulinicacid,ALA）光动力治疗顽固性扁平疣的临床疗效.方法 采用随机对照的方法将120例扁平疣患者分为两组：对照组60例,采用10％ALA光动力治疗,应用LED光源照射,功率密度70 mW/cm2,距离20 cm,照射20 min;观察组60例,采用点阵激光500～800 J/脉冲,短脉冲模式预处理后再使用10％ALA光动力治疗.治疗2次,每次间隔2周.治疗结束3个月后进行随访,记录皮损消退情况和不良反应.结果 观察组经2次治疗后痊愈率86.44％,对照组治疗后痊愈率59.65％,观察组有效率高于对照组,差异有统计学意义（P＜0.05）.3个月后随访,观察组复发率3.39％,对照组复发率12.30％,观察组复发率低于对照组,差异有统计学意义（P＜0.05）.两组均无明显不良反应.结论 低剂量点阵激光能促进ALA的透皮吸收,提高光动力的疗效.Objective To evaluate the efficacy of combined therapies of ablative fractional Er ∶YAG laser （2,940 nm） and ALA-PDT on refractory verruca plana.Methods 120 cases of refractory verruca plana patients were randomly divided into two groups：60 cases in the control group and 60 cases in the experimental group.The control group used 10% ALA-PDT with LED irradiation of a power density 70 of mW/cm2 at a distance of 20 cm,which lasted for 20 min each time.The experimental group was treated with ablative fractional Er ∶ YAG laser （2,940 nm） first with the fluence of 500P/cm2 and short pulse duration,and then treated 10% ALA-PDT as mentioned before.Every patient was treated twice at two-week intervals.Three independent investigators evaluated subject outcomes at 3 months post-treatment including efficacy and side-effects.Results The effective rate of the experimental group was 86.44 % at 3 months post-treatment after one to two times.Meanwhile,the control group was 59.65 %.The clinical outcome of experimental group was better than the control group.There was significant difference between the two groups （P〈0.05）.The recurrent rate of experimental group was 3.39% and 12.30% in control group.There was significant difference between the two groups （P〈0.05）.There were no obvious side-effects in both groups.Conclusions Ablative fractional laser with low fluence promotes the transdermal absorption of ALA and enhances the efficacy of PDT.

关 键 词：点阵激光 光动力治疗 扁平疣 5-氨基酮戊酸 

分 类 号：R752.52[医药卫生—皮肤病学与性病学]