抑郁症共病胃肠疾病的神经生物学机制研究进展  

Advances in neurobiological mechanisms of comorbid depression and gastrointestinal disease

作　　者：张涛[1,2] 令狐婷[1,2,3] 张潇 田俊生[1,2] 秦雪梅[1,2] 

机构地区：[1]山西大学中医药现代研究中心,太原030006 [2]山西大学地产中药功效物质研究与利用山西省重点实验室,太原030006 [3]山西大学化学化工学院,太原030006

出　　处：《生理学报》2018年第1期71-78,共8页Acta Physiologica Sinica

基　　金：中国博士后科学基金项目(No.2016M602414);山西省科技重点研发计划(No.201603D3113013;201603D321077);地产中药功效物质研究与利用山西省重点实验室项目(No.201605D111004);山西省科技创新重点团队项目(No.201605D131045-18)资助

摘　　要：抑郁症是一种常见的心境障碍性疾病,对人群健康的危害日益加重。胃肠疾病是一类兼具动力学改变和器质性病变的系列疾病,主要包括功能性胃肠病、胃食管反流病、胃炎、胃溃疡。近年来,抑郁症共病胃肠疾病的现象普遍,但是在临床诊疗过程中,患者多被医生诊断为单方面抑郁症或胃肠疾病,造成患者治疗延迟,甚至无效。本文综述了抑郁症共病胃肠疾病的一些临床症状表现,并以两者涉及的可能发病机制为出发点,找寻其共病的神经生物学通路,从而提高人们对抑郁症共病胃肠疾病的重视程度,并为共病的临床与基础研究及兼具治疗作用的药物研发提供依据。Depression is a common mood disorder, which is harmful to public health critically. Gastrointestinal diseases are a series of diseases with both dynamic changes and organic disease, including functional gastrointestinal disease, gastroesophageal reflux disease, gastritis, and gastric ulcer. In recent years, the phenomena of comorbid depression and gastrointestinal disease have become common, however, most patients were diagnosed as unilateral depression or gastrointestinal disease in the clinical treatment process, resulting in delayed treatment or even invalid. The present review focuses on some of the clinical symptoms of comorbid depression and gastrointestinal disease, and begins to explore the possible pathogenesis, so as to find out the potential neurobiological pathways of comorbidity. Consequently, the more attention on comorbid depression and gastrointestinal disease will be paid, and the clinical and basic research of comorbidity and the drug development will be provided.

关 键 词：抑郁症 胃肠疾病 共病 神经生物学通路 发病机制 

分 类 号：R338[医药卫生—人体生理学]