血凝素样氧化低密度脂蛋白受体-1与动脉粥样硬化的研究进展  

Recent advances in Lectin-Like oxidized Low-density Lipoprotein receptor-1 and atherosclerosis

作　　者：苏瑞[1] 张敏[1] 肖践明[1] 

机构地区：[1]昆明医科大学第一附属医院心内科,云南昆明650032

出　　处：《临床医学》2017年第10期124-126,F0003,F0004,共5页Clinical Medicine

摘　　要：凝素样氧化低密度脂蛋白受体-1(LOX-l)是动脉血管内皮细胞上氧化低密度脂蛋白(ox-LDL)的特异性受体。LOX-1的表达可导致内皮细胞功能障碍和凋亡、平滑肌细胞增殖和迁移、诱导炎症及单核细胞黏附、泡沫细胞形成、斑块的不稳定和血小板的激活等,所有这些事件都是动脉粥样硬化(AS)发病机制的关键。因此对LOX-1的研究不仅有助于了解AS的发病机制,还可能找到防治AS的潜在靶点。本研究对LOX-1的生物学特性及其在AS中作用的最新研究进展进行综述。Lectin-Like oxidized Low-density Lipoprotein receptor-1（LOX-l） is specific receptor of oxidized Low-density Lipoprotein（ox-LDL） on arterial endothelial cells.The expression of LOX-1 can cause the dysfunction of endothelial cell and apoptosis of endothelial cell,proliferation of smooth muscle cells and migration of smooth muscle cells,inflammation and adhesion of mononuclear cell adhesion,the formation of foam cells,the unstable plaque instability and activate platelet activation,etc,which are the crucial points to the pathogenesis of atherosclerosis（AS）.So the study of LOX-1 can not only helps to understand the pathogenesis of AS,but also finds the potential targets of the prevention and treatment of the AS.This paper gives a synthetic survey about the latest research progress about the biological characteristics of LOX-1,and its role in the AS were summarized.

关 键 词：血凝素样氧化低密度脂蛋白受体-1 动脉粥样硬化 泡沫细胞 

分 类 号：R543.5[医药卫生—心血管疾病]