芪参益气滴丸对ApoE基因敲除小鼠动脉粥样硬化中调节性T细胞的影响  

Effects of Qishen Yiqi Dripping Pills on regulatory T cells in Apo E gene knockout mice with atherosclerosis

作　　者：彭立[1] 沈佳成 王亚东[1] 吕崇山[1] 赵云[1] 卢大为[1] 黄淑琼[1] 杨宗保[1] 钱林超[1] 文磊[1] 

机构地区：[1]厦门大学医学院,厦门361102

出　　处：《中华中医药杂志》2018年第3期907-910,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：福建省自然科学基金项目(No.2016J01413);广东省自然科学基金项目(No.2016A030313860);教育部留学回国人员科研启动基金项目(No.2015-311);教育部"新世纪优秀人才支持计划"项目(No.NCET-13-0505);国家重点研发计划"重大慢性非传染性疾病防控研究"重点专项(No.2016YFC1305903)~~

摘　　要：目的:研究芪参益气滴丸对动脉粥样硬化中调节性T细胞的影响。方法:采用6周龄雄性C57BL/6J小鼠和Apo E基因敲除小鼠,分为正常组、模型组、芪参低剂量组、芪参高剂量组,每组6只。除正常组外,其他3组小鼠均给予高脂饲料喂养,药物组还给予高、低剂量的芪参益气滴丸,8周后评价内脏指数、动脉粥样硬化病变、调节性T细胞情况。结果:与模型组比较,芪参高剂量组可显著降低肝指数(P<0.05),减少动脉粥样硬化斑块面积(P<0.05,P<0.01),并增加脾脏调节性T细胞数量(P<0.01)。结论:芪参益气滴丸可能通过增加脾脏调节性T细胞数量抑制动脉粥样硬化形成。Objective： To study the effect of of Qishen Yiqi Dripping Pills（QSYQ） on regulatory T cells in atherosclerosis. Methods： Six-week male C57 BL/6 J mice and Apo E gene knockout mice were randomly divided into control group, model group, QSYQ low dosage group and QSYQ high dosage group, six mice in each group. Except for the control group, mice in the other three groups were fed with high fat diet, and those in the drug treatment groups were administered with high or low dosage QSYQ respectively at the same time. Internal organs index, aortic atherosclerosis lesion and regulatory T cells were determined. Results： Compared with model group, QSYQ could significant decreased liver index（P〈0.05）, attenuate aortic atherosclerotic plaque area（P〈0.05, P〈0.01）, and increase the quantity of regulatory T cells in spleen（P〈0.01）. Conclusion： QSYQ might inhibit the formation of atherosclerosis by increasing the quantity of regulatory T cells in spleen.

关 键 词：动脉粥样硬化 斑块 芪参益气滴丸 调节性T细胞 

分 类 号：R285.5[医药卫生—中药学]