基于集对分析势值成果的寻常型银屑病血热证临床再研究  

Clinical re-study on blood heat syndrome of psoriasis vulgaris based on set pair analysis potential results

作　　者：洪锡京 许逊哲 蒯仂 茹意 魏冬慧 吴人杰[3] 李欣[1,2] 李斌[1,2] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437 [2]上海市中医药研究院皮肤病研究所,上海201203 [3]上海中医药大学,上海201203

出　　处：《中华中医药杂志》2018年第3期1160-1163,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81473682);国家基础科学人才培养基金项目(No.J1103607);上海市卫计委项目(No.ZY3-CCCX-3-3033);上海市科委项目(No.14401970200);上海中医药大学第十批大学生科创项目(No.JX61.08.97;No.JX61.08.98)~~

摘　　要：目的:通过随机对照(RCT)临床研究评价既往集对分析势值理论得出的方案治疗银屑病血热证的临床疗效。方法:纳入标准符合的寻常型银屑病血热证60例,使用随机数字表随机分为2组,传统辨证组30例,用犀角地黄汤为基本方随证加减;集对分析势值成果组30例,以课题组前期病例回顾及临床观察的中药通过经典统计和集对分析势值成果方法共得到15种中药为基本方随证加减。观察4周,指标包括PASI评分法及Zung焦虑量表(SAS)及Zung抑郁量表。结果:临床研究显示,集对分析势值成果组有效率为93.10%,愈显率为58.62%。传统辨证组有效率为96.55%,愈显率为41.38%,集对分析势值成果组优于传统辨证组(P<0.05)。两组均能降低银屑病临床症状PASI评分(P<0.01),集对分析势值成果组优于传统辨证组(P<0.01);同时两组均能降低患者Zung指数评分(P<0.01),传统辨证组效果优于集对分析势值成果组(P<0.01)。结论:基于集对分析势值成果的方剂是临床治疗寻常型银屑病血热证的有效方剂,显著改善患者临床证候且提高生活质量,作为辨病论治基本方值得进一步推广应用。Objective： The randomized controlled（RCT） clinical study was used to evaluate the clinical efficacy of the previous study on the analysis of potential value theory for the treatment of psoriasis blood-heat syndrome. Methods： Inclusion criteria consistent with psoriasis 60 cases of blood heat syndrome, they were randomly divided into two groups, traditional syndromes group which were treated with Xijiaodihuang Decoction with syndrome. Thirty cases in set pairs of potential results group based on the previous case review and clinical observation of traditional Chinese medicine, through the classical statistics and set pairs of potential value method, a total of 15 kinds of Chinese medicine as the basic side card with card addition and subtraction. Observe for 4 weeks, indicators include PASI score and Zung anxiety scale（SAS） and Zung depression scale. Results： Clinical research shows, the effective rate of set pair analysis potential results group was 93.10%, The more obvious rate was 58.62%. The traditional syndrome differentiation efficiency was 96.55%, The more obvious rate was 41.38%. Difference between the two groups was statistically significant（P〈0.05）. Set pair analysis potential outcome group is better than the traditional syndrome group（P〈0.01）. Both groups could reduce PASI scores of clinical symptoms of psoriasis（P〈0.01）, set pair analysis potential outcome group is better than the traditional syndrome group, while reducing patient Zung depression scores（P〈0.01）, the traditional syndrome group is better than the set pair potential value analysis group（P〈0.01）. Conclusion： Prescriptions based on set-pair analysis of potency outcomes are an effective prescription for the clinical treatment of psoriasis-related blood-heat syndromes. Significantly improve patient clinical syndromes and improve quality of life, as the basic theory of differentiation of diseases worthy of further promotion and application.

关 键 词：集对分析 临床研究 寻常型银屑病 

分 类 号：R275.9[医药卫生—中西医结合]