滋阴润燥法治疗阴虚内燥型2型糖尿病干眼症的临床观察  

Clinical observation on treatment of ophthalmoxerosis in type 2 diabetes mellitus with endogenous heat due to yin deficiency type by nourishing yin for moistening dryness

作　　者：肖采尹 许家骏[1] 张南[1] 李铁军[1] 曹旭[1] 粱向红 王晓聃 赵玲 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医医院顺义医院,北京101300

出　　处：《中华中医药杂志》2018年第3期1191-1193,共3页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨滋阴润燥法治疗阴虚内燥型2型糖尿病(T2DM)干眼症的临床疗效及安全性。方法:阴虚内燥型T2DM干眼症患者60名(120眼),随机分为中药组30例(60眼)和对照组30例(60眼)。中药组用滋阴润燥法方内服外熏相结合,对照组以聚乙烯醇滴眼液点眼,每日4次。用药0、14、28d时记录患者眼部自觉症状评分、泪膜破裂时(BUT)、泪液分泌试验(SIT)、泪荧光素染色(FL)、角膜知觉检测评分,并进行组内、组间对比。分析总结滋阴润燥法对阴虚内燥型T2DM干眼症的临床疗效及安全性。结果:中药组的总有效率显著优于对照组(P<0.05)。两组均未出现药物不良反应。两组患者客观指标比较:中药组治疗14d时SIT、角膜知觉优于对照组(P<0.05,P<0.01),治疗28d时,仅SIT有统计学意义(P<0.05)。自身用药前后对比:中药组BUT、SIT、FL均有统计学意义(P<0.05,P<0.01),对照组BUT、SIT有统计学意义(P<0.05,P<0.01)。两组患者眼部症状评分比较:治疗14d时异物感对照组优于中药组(P<0.01),治疗28d时烧灼感、视疲劳、眼痒、眼红中药组优于对照组(P<0.01);自身用药前后对比:中药组干涩感、烧灼感、视疲劳、眼痒、畏光、眼红显著改善(P<0.05,P<0.01),对照组干涩感、异物感、视疲劳显著改善(P<0.01)。结论:滋阴润燥方能有效治疗阴虚内燥型T2DM性干眼症,且安全性较高。不仅能提高患者的泪膜稳定性,增加基础泪液分泌,还能在一定程度上对角膜上皮进行修复,在治疗中对患者的自觉症状有较好的改善作用,总体疗效优于对照组。Objective： To investigate the clinical efficacy and safety of nourishing yin for moistening dryness in treating ophthalmoxerosis in type 2 diabetes mellitus（T2 DM） with endogenous heat due to yin deficiency type. Methods： Sixty patients（120 eyes） with ophthalmoxerosis in T2 DM with endogenous heat due to yin deficiency type were randomly divided into treatment group（30 cases, 60 eyes） and control group（30 cases, 60 eyes）, the patients in treatment group were treated with nourishing yin for moistening dryness method, while the patients in control group were treated with Polyvinyl Alcohol Eye Drops for 4 times a day. The ocular symptoms score, tear break-up time（BUT）, Schirmer test（SIT）, tear fluorescein staining（FL） and corneal perception test score were recorded at day 0, day 14 and day 28, then group and group comparisons was conducted to analyze and summarize the clinical efficacy and safety of nourishing yin for moistening dryness method in treating ophthalmoxerosis. Results： After treatment, the total effective rate of the treatment group was better than that of control group（P〈0.05）. No adverse reactions occurred in the two groups. Objective index comparisons between groups： corneal sensation contrast was statistically significant at day 14（P〈0.05, P〈0.01）, only SIT was statistically significant at day 28（P〈0.05）. Self-medication comparisons： BUT, SIT, FL in treatment group were statistically significant（P〈0.05, P〈0.01）, BUT and SIT in control group were statistically significant（P〈0.05, P〈0.01）. Ocular symptoms scores： foreign body sensation was statistically significant at day 14（P〈0.01）, burning sensation, visual fatigue, eye itching, dryness, foreign body sensation, burning sensation, photophobia, redness at day 28 were statistically significant（P〈0.01）. Self-contrast before and after treatment： in treatment group, dryness, burning sensation, visual fatigue, eye itching, photophobia and redness were statistical sign

关 键 词：滋阴润燥 阴虚内燥 2型糖尿病 干眼症 

分 类 号：R259[医药卫生—中西医结合]