血红蛋白水平与非酒精性脂肪性肝病发生风险相关性队列研究  

Hemoglobin level is a risk factor of non-alcoholic fatty liver disease

作　　者：刘安楠[1] 潘洁[2] 王蕾蕾[1] 杨书文[1] 张晏[1] 付静[1] 曹素艳[1] Liu AN;Wang LL;Yang SW;Zhang Y;Fu J;Cao SY;Pan J(Department of Special Medical Care, Beijing Hospital, National Center of Gerontology, Belting 100730, China;Medical Examination Center, Beijing Hospital, National Center of Gerontology, Beijing 100730, China)

机构地区：[1]北京医院特需医疗部,100730 [2]北京医院体检中心,100730

出　　处：《中华全科医师杂志》2018年第2期130-132,共3页Chinese Journal of General Practitioners

摘　　要：将732例2009年在北京医院体检中心进行体检、年龄30～60岁、无非酒精性脂肪性肝病（NAFLD）的体检者，按照血红蛋白水平四分位分为4组，其中血红蛋白水平≤131 g/L者192例，为Q1组；〉131 g/L～≤140 g/L者178例，为Q2组；〉140 g/L～≤152 g/L者184例，为Q3组；〉152 g/L者178例，为Q4组。随访至2013年，NAFLD的患病率随着基线血红蛋白水平的增高而增加，Q1、Q2、Q3和Q4组分别为8.3%（16/192）、17.4%（31/178）、23.4%（43/184）和25.3%（45/178），差异有统计学意义（P〈0.05）；logistic回归分析显示，Q2、Q3和Q4组NAFLD的OR值为Q1组的2.32（1.22～4.41）、3.36（1.81～6.21）和3.72（2.02～6.87）倍（均P〈0.05）；多元logistic回归分析显示血红蛋白水平、TG、BMI是NAFLD发病的独立危险因素。Total 732 subjects aged 30-60 years undergoing health check-up at Beijing Hospital Medical Examination Center in 2009, who had no history of non-alcoholic fatty liver disease （NAFLD） were recruited in the study.According to the quartile of hemoglobin （HGB） level, the subjects were divided into 4 groups： Q1： HGB≤131 g/L （n=192）, Q2： HGB〉131 g/L and ≤140 g/L （n=178）, Q3： HGB〉140 g/L and ≤152 g/L （n=184）, Q4： HGB〉152 g/L （n=178）. All participants were followed up for 4 years, the prevalence rates of NAFLD in groups Q1, Q2, Q3 and Q4 were 8.3% （16/192）, 17.4% （31/178）, 23.4% （43/184） and 25.3% （45/178）, respectively （P〈0.05）. Logistic regression showed that the rates of NAFLD in groups Q2, Q3 and Q4 were 2.32 （1.22-4.41）, 3.36 （1.81-6.21） and 3.72（2.02-6.87） times higher as group Q1（P〈0.05）. Multiple logistic regression analysis showed that the hemoglobin level, TG and BMI were the independent risk factors of NAFLD.

关 键 词：脂肪肝 血红蛋白类 队列研究 

分 类 号：R446.1[医药卫生—诊断学] R575.5[医药卫生—临床医学]