Interferon-Gamma Release Assay is Not Appropriate for the Diagnosis of Active Tuberculosis in High-Burden Tuberculosis Settings: A Retrospective Multicenter Investigation  被引量:31

Interferon-Gamma Release Assay is Not Appropriate for the Diagnosis of Active Tuberculosis in High-Burden Tuberculosis Settings: A Retrospective Multicenter Investigation

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作  者:Wan-Li Kang Gui-Rong Wang Mei-Ying Wu Kun-Yun Yang Er-Tai A Shu-Cai Wu Shu-Jun Geng Zhi-Hui Li Ming-Wu Li Liang Li Shen-Jie Tang 

机构地区:[1]Epidemiology Research Department, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China [2]Tuberculosis Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China [3]Department of Tuberculosis, Souzhou 5th People's Hospital, Souzhou, Jiangsu 215007, China [4]Department of Tuberculosis, Hunan Chest Hospital, Changsha, Hunan 410013, China [5]Department of Tuberculosis, Chest Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830049, China [6]Department of Tuberculosis, Hebei Chest Hospital, Shijiazhuang, Hebei 050041, China [7]Department of Tuberculosis, Kunming 3rd People's Hospital, Kunming, Yunnan 650041, China [8]Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149,China

出  处:《Chinese Medical Journal》2018年第3期268-275,共8页中华医学杂志(英文版)

摘  要:Background:Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis,but the results from different high TB-endemic countries are different.The aim of this study was to investigate the value of IGRA in the diagnosis of active pulmonary TB (PTB) in China.Methods:We conducted a large-scale retrospective multicenter investigation to further evaluate the role of IGRA in the diagnosis of active PTB in high TB-epidemic populations and the factors affecting the performance of the assay.All patients who underwent valid T-SPOT.TB assays from December 2012 to November 2015 in six large-scale specialized TB hospitals in China and met the study criteria were retrospectively evaluated.Patients were divided into three groups:Group 1,sputum culture-positive PTB patients,confirmed by positive Mycobacterium tuberculosis sputum culture;Group 2,sputum culture-negative PTB patients;and Group 3,non-TB respiratory diseases.The medical records of all patients were collected.Chi-square tests and Fisher's exact test were used to compare categorical data.Multivariable logistic analyses were performed to evaluate the relationship between the results of T-SPOT in TB patients and other factors.Results:A total of 3082 patients for whom complete information was available were included in the investigation,including 905 sputum culture-positive PTB cases,914 sputum cultmre-negative PTB cases,and 1263 non-TB respiratory disease cases.The positive rate of T-SPOT.TB was 93.3% in the culture-positive PTB group and 86.1% in the culture-negative PTB group.In the non-PTB group,the positive rate of T-SPOT.TB was 43.6%.The positive rate of T-SPOT.TB in the culture-positive PTB group was significantly higher than that in the culture-negative PTB group (x2 =25.118,P 〈 0.01),which in turn was significantly higher than that in the non-TB group (x2 =566.l 16,P 〈 0.01).The overall results were as follows:sensitivity,89.7%;specificity,56.37%;positive predictive value,74.75%;negBackground:Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis,but the results from different high TB-endemic countries are different.The aim of this study was to investigate the value of IGRA in the diagnosis of active pulmonary TB (PTB) in China.Methods:We conducted a large-scale retrospective multicenter investigation to further evaluate the role of IGRA in the diagnosis of active PTB in high TB-epidemic populations and the factors affecting the performance of the assay.All patients who underwent valid T-SPOT.TB assays from December 2012 to November 2015 in six large-scale specialized TB hospitals in China and met the study criteria were retrospectively evaluated.Patients were divided into three groups:Group 1,sputum culture-positive PTB patients,confirmed by positive Mycobacterium tuberculosis sputum culture;Group 2,sputum culture-negative PTB patients;and Group 3,non-TB respiratory diseases.The medical records of all patients were collected.Chi-square tests and Fisher's exact test were used to compare categorical data.Multivariable logistic analyses were performed to evaluate the relationship between the results of T-SPOT in TB patients and other factors.Results:A total of 3082 patients for whom complete information was available were included in the investigation,including 905 sputum culture-positive PTB cases,914 sputum cultmre-negative PTB cases,and 1263 non-TB respiratory disease cases.The positive rate of T-SPOT.TB was 93.3% in the culture-positive PTB group and 86.1% in the culture-negative PTB group.In the non-PTB group,the positive rate of T-SPOT.TB was 43.6%.The positive rate of T-SPOT.TB in the culture-positive PTB group was significantly higher than that in the culture-negative PTB group (x2 =25.118,P 〈 0.01),which in turn was significantly higher than that in the non-TB group (x2 =566.l 16,P 〈 0.01).The overall results were as follows:sensitivity,89.7%;specificity,56.37%;positive predictive value,74.75%;neg

关 键 词:Active Tuberculosis DIAGNOSIS Interferon-Gamma Release Assay 

分 类 号:TS101.923[轻工技术与工程—纺织工程] O614.123[轻工技术与工程—纺织科学与工程]

 

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