双甲基丙烯酸二缩三乙二醇酯细胞毒性的研究进展  

Cytotoxic mechanism of triethylene glycol dimethacrylate

作　　者：陈秀春[1] 张志民[1] 洪丽华[1] 张雅琪[1] 郑鹏[1] 李文月[1] 

机构地区：[1]吉林省牙发育及颌骨重塑与再生重点实验室吉林大学口腔医院牙体牙髓病科,长春130021

出　　处：《国际口腔医学杂志》2018年第2期209-213,共5页International Journal of Stomatology

基　　金：吉林省产业创新专项资金(2016c045-3)

摘　　要：细胞毒性是一种由细胞或化学物质引起的单纯细胞杀伤事件,是化学物质作用于细胞基本结构和/或生理过程,如细胞膜或细胞骨架结构,细胞的新陈代谢过程,细胞组分或产物的合成、降解或释放,离子调控及细胞分裂等过程,导致细胞存活、增殖和/或功能的紊乱,从而引发的不良反应。双甲基丙烯酸二缩三乙二醇酯(TEGDMA)是牙科树脂材料中常用的稀释单体,也是树脂基质成分中引起细胞毒性的重要相关单体,可以引起细胞体内氧化平衡失调、细胞凋亡、DNA损伤等一系列毒性反应。本文就TEGDMA引起的细胞毒性研究进展进行综述,旨在为进一步明确其产生毒性的机制,减弱或消除其毒性作用奠定基础。Cell toxicity is a pure cell killing event caused by a cell or chemical substances. The chemical substances act on the basic structure of the cell and/or physiological processes, such as cell membrane and cytoskeleton structure, cell metabolism, synthesis of cellular components or products, degradation or release, ion regulation and cell division. Which leads to adverse reactions such as cell survival, proliferation and/or functional disorder. Triethylene glycol dimethacrylate （TEGDMA） is a commonly used diluent of many resin-based dental composites. It is an important relevant monomer responsible for the cytotoxicity of the resin matrix. The monomer can lead to a series of toxic reactions, such as oxidative imbalance, apoptosis, DNA damage and so on. In this paper, the research advances in mechanism of cytotoxicity induced by TEGDMA monomer is reviewed, the aim is to lay the foundation for further clarifying the mechanism of toxicity and to reduce or eliminate the toxic effect.

关 键 词：双甲基丙烯酸二缩三乙二醇酯 氧化应激 细胞毒性 基因毒性 细胞凋亡 

分 类 号：Q256[生物学—细胞生物学]