氩氦刀冷冻治疗的抗肿瘤免疫学机制研究进展  

Progress of antitumor immunological mechanisms of Argon-helium cryosurgical system

作　　者：陈亚斌 李冉冉 郭文治[1] 

机构地区：[1]郑州大学第一附属医院肝胆外科,450052 [2]河南省人民医院肿瘤科,郑州450052

出　　处：《免疫学杂志》2018年第3期259-264,共6页Immunological Journal

基　　金：国家自然科学基金(81671958)

摘　　要：氩氦刀利用氩气快速制冷产生超低温(<-140℃)及氦气快速复温引起细胞内外冰晶形成、细胞脱水等机制导致肿瘤细胞死亡。氩氦刀冷冻治疗的抗肿瘤免疫效应得到了广泛的研究,多数研究表明冷冻治疗可以增强机体抗肿瘤免疫效应,冷冻治疗后肿瘤坏死物质持续释放入血,致敏树突状细胞,增强其抗原提呈能力并促进其分泌IL-4、IL-12等多种细胞因子,进而促进T细胞、B细胞的增殖与活化,使机体免疫系统激活而发挥抗肿瘤作用。而另一些研究发现冷冻治疗后发生了高带免疫耐受,使Treg细胞增殖及活性增加,抑制了机体的抗肿瘤免疫效应。近年来,氩氦刀联合CpG-ODN、CTLA-4抗体等其他免疫治疗方式取得了良好的治疗效果。本文通过回顾国内外文献,对氩氦刀冷冻治疗的抗肿瘤免疫学机制研究进展进行概述。The mechanisms of Argon-helium cryosurgical system are argon rapid refrigeration generating ultra low temperature（〈-140 ℃） and helium rapid rewarming causing ice crystals formation inside and outside cells,eventually leading to tumor cells dehydration and death. The antitumor immune effect of cryotherapy has been extensively studied, and most studies show that cryotherapy can enhance the antitumor immune effect. Cryotherapy could promote many necrosis substance of tumor to release into blood, then activate dendritic cells and enhance their ability of presenting antigens. Activated dendritic cells also secrete many kinds of cytokines such as IL-4 and IL-12, then promote the activation and proliferation of T lymph cells and B lymph cells, thus activate immune system to exert anti-tumor immune effect. Other studies have found that high-zone tolerance has occurred after cryotherapy, which increases the proliferation and activity of Treg cells and inhibits the anti-tumor immune effect.In recent years, Argon-helium cryosurgical system combine with Cp G-ODN, CTLA-4 antibodies or other immunotherapy achieved good therapeutic effect. In this paper, we overview the research progress about antitumor immunological mechanisms of Argon-helium cryosurgical system.

关 键 词：氩氦刀 冷冻治疗 抗肿瘤效应 免疫学效应 

分 类 号：R392.9[医药卫生—免疫学]