促性腺平抑因子在女性生殖方面的研究进展  

Progress of Gonadotrophin surge-attenuating factor in female reproduction

作　　者：刘小惠[1] 吴小华 

机构地区：[1]河北医科大学,石家庄050017 [2]白求恩国际和平医院,石家庄050082

出　　处：《中国优生与遗传杂志》2018年第2期123-125,共3页Chinese Journal of Birth Health & Heredity

基　　金：2013年全军后勤科研项目(项目编号:BBJ13C001)

摘　　要：促性腺平抑因子(GnSAF)是由卵泡刺激激素(FSH)刺激卵巢产生的一种可以降低垂体对促性腺激素释放激素(GnRH)反应的蛋白分子,其主要作用是抵抗雌激素,从而负反馈调节黄体生成激素(LH)合成与分泌,参与卵泡募集、生长发育、排卵,并与卵巢反应性、子宫内膜容受性及控制性超促排卵(COH)结局等女性生殖活动密切相关。Gonadotrophin surge-attenuating factor（GnSAF）,a protein molecule,which is produced by ovaries under the stimulation of follicle stimulating hormone,can reduce the reaction of pituitary gland to gonadotropin-releasing hormone（GnRH）. Its primary role is to resist to estrogen,and regulate the synthesis and secrection of luteinizing hormone（LH）by negative feedback regulation mechanism. And then,participate in follicular recruitment,growth and development as well as ovulation. Furthermore,GnSAF is closely related with female reproductive activities such as ovarian reaction,endetrial receptivity,controlled ovarian hyperstimulation（COH）outcomes and so on.

关 键 词：促性腺平抑因子 黄体生成激素 控制性超促排卵 

分 类 号：R349-64[医药卫生—基础医学]